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EHU010411

Sigma-Aldrich

MISSION® esiRNA

targeting human PGP

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UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

GACCCGCACTTCAGCTACATGAAGCTCACCAAGGCCCTGCGCTACCTGCAGCAGCCCGGCTGCCTGCTCGTGGGCACCAACATGGACAACCGGCTTCCGCTTGAGAACGGCCGCTTCATCGCGGGTACCGGGTGTCTGGTCCGAGCCGTGGAGATGGCCGCCCAGCGCCAGGCCGACATCATCGGGAAGCCCAGCCGCTTCATTTTCGACTGCGTGTCCCAGGAATACGGCATCAACCCCGAGCGCACCGTCATGGTGGGAGACCGCCTGGACACAGACATCCTCCTAGGCGCCACCTGTGGCCTGAAGACCATCCTGACCCTCACCGGAGTCTCCACTCTAGGGGATGTGAAGAATAATCAGGAAAGTGACTGCGTGTCTAAGAAGAAAATGGTCCCTGACTTCTATGTTGACAGCATAGCCGACCTTTTG

Ensembl | human accession no.

ENSG00000184207

NCBI accession no.

NM_001042371

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... PGP(283871) , PGP(283871)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Patric J Jansson et al.
The Journal of biological chemistry, 290(15), 9588-9603 (2015-02-28)
Multidrug resistance (MDR) is a major obstacle in cancer treatment. More than half of human cancers express multidrug-resistant P-glycoprotein (Pgp), which correlates with a poor prognosis. Intriguingly, through an unknown mechanism, some drugs have greater activity in drug-resistant tumor cells

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