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EHU001321

Sigma-Aldrich

MISSION® esiRNA

targeting human MIOX

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UNSPSC Code:
41105324
NACRES:
NA.51

description

Powered by Eupheria Biotech

Quality Level

100

product line

MISSION®

form

lyophilized powder

esiRNA cDNA target sequence

GACTCCACCTTCCAGGACAACCCTGACCTCCAGGATCCTCGATACAGCACAGAGCTCGGGATGTATCAGCCCCACTGTGGGCTCGACAGGGTCCTCATGTCCTGGGGCCATGATGAGTACATGTACCAGGTGATGAAGTTTAACAAGTTCTCACTGCCCCCTGAGGCTTTCTACATGATCCGGTTCCACTCCTTCTACCCCTGGCACACGGGCCGCGACTACCAGCAGCTGTGCAGCCAGCAGGACCTGGCCATGCTGCCCTGGGTGCGGGAGTTCAACAAGTTCGACCTCTACACCAAGTGCCCGGACCTGCCGGACGTGGACAAGCTGCGGCCCTACTACCAGGGGCTCATTGACAAGTACTGCCCTGGCATCCTGAGCTGGTGACCCTCCTGCCACCCAAGCTGCTGCTGGACCTAGGCCTGGCCCTCCGCCTGCCTGGAGAGGCCTGGCCCTGGGCAAACAGCCGCCATCAGGGTTCACCTCGGTGGGGGACCCCACTCACCCCCTTAGGGTCGCCACCCCTCACGGCAACTTGTGCCTGGCGTCAATAAAGACCTGGAAGGATGTTGTGCT

Ensembl | human accession no.

ENSG00000100253

NCBI accession no.

NM_017584

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... MIOX(55586) , MIOX(55586)

General description

MISSION® esiRNA are endoribonuclease prepared siRNA. They are a heterogeneous mixture of siRNA that all target the same mRNA sequence. These multiple silencing triggers lead to highly-specific and effective gene silencing.

For additional details as well as to view all available esiRNA options, please visit SigmaAldrich.com/esiRNA.

Legal Information

MISSION is a registered trademark of Merck KGaA, Darmstadt, Germany

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Tatsuya Tominaga et al.
The Journal of biological chemistry, 291(3), 1348-1367 (2015-11-19)
The kidney is one of the target organs for various metabolic diseases, including diabetes, metabolic syndrome, and obesity. Most of the metabolic studies underscore glomerular pathobiology, although the tubulo-interstitial compartment has been underemphasized. This study highlights mechanisms concerning the pathobiology
Isha Sharma et al.
Biomedicines, 8(7) (2020-07-28)
Obesity is associated with perturbations in cellular energy homeostasis and consequential renal injury leading to chronic renal disease (CKD). Myo-inositol oxygenase (MIOX), a tubular enzyme, alters redox balance and subsequent tubular injury in the settings of obesity. Mechanism(s) for such

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