E9905
Anti-Endothelin B Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
Synonym(s):
Anti-ET-B Receptor
Product Name
Anti-Endothelin B Receptor antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunocytochemistry: 4-11 μg/mL using human adrenal tissue
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-11 μg/mL using human adrenal tissue
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EDNRB(1910)
mouse ... Ednrb(13618)
rat ... Ednrb(50672)
Application
Anti-Endothelin B Receptor antibody produced in rabbit is suitable for the following applications:
- Immunocytochemistry at a concentration of 4-11μg/mL using human adrenal tissue
- Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4-11μg/mL using human adrenal tissue
- Western blotting
- Immunofluorescence
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
EDNRB Endothelin receptor type B (ETB) is a protein encoded by the EDNRB gene in humans. It plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
synthetic peptide corresponding to the N-terminal extracellular domain of human endothelin B receptor, conjugated to KLH. The immunizing peptide has 79% homology with the mouse gene and 84% homology with the rat gene.
Physical form
Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Overexpression of endothelin B receptor in glioblastoma: a prognostic marker and therapeutic target?
Suhas Vasaikar et al.
BMC cancer, 18(1), 154-154 (2018-02-08)
Glioblastoma (GBM) is the most common malignant brain tumor with median survival of 12-15 months. Owing to uncertainty in clinical outcome, additional prognostic marker(s) apart from existing markers are needed. Since overexpression of endothelin B receptor (ETBR) has been demonstrated in
T Tanaka et al.
British journal of cancer, 110(4), 1027-1033 (2013-12-21)
The endothelin axis has been shown to have a pivotal role in several human malignancies. The aim of this study was to clarify the clinical importance of endothelin receptor type B (ETBR) in human oesophageal squamous cell carcinoma (OSCC). We
J Milara et al.
British journal of pharmacology, 161(7), 1599-1615 (2010-08-12)
Pulmonary arteries from smokers and chronic obstructive pulmonary disease patients show abnormal endothelium-dependent vascular reactivity. We studied the effect of cigarette smoke extract (CSE) on endothelin receptor B (ET(B) ) expression in human pulmonary artery endothelial cells (HPAECs) and its
Amanda J Leblanc et al.
Microcirculation (New York, N.Y. : 1994), 20(5), 365-376 (2012-12-04)
The risk for cardiovascular disease increases with advancing age; however, the chronological development of heart disease differs in males and females. The purpose of this study was to determine whether age-induced alterations in responses of coronary arterioles to the endogenous
Xin Wan et al.
Molecular medicine reports, 9(1), 229-234 (2013-10-23)
In this study, the role of the endothelin B receptor (ETBR) in oligodendroglioma cell proliferation and survival was investigated in vitro and in vivo. The overexpression and knockdown of ETBR was conducted in Hs683 human oligodendroglioma cells, and cell proliferation and activation (phosphorylation)
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