E9780
Anti-Endothelin A Receptor antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
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Synonym(s):
EDNRA, ENDOR, ET-AR, ETA, ETA RECEPTOR, ETRA, Endothelin Receptor Type A, Et1 receptor, Gpcr10, RATENDOR, Anti-ET-A Receptor
Recommended Products
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 3-16 μg/mL using human heart tissue
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
target post-translational modification
unmodified
Gene Information
human ... EDNRA(1909)
mouse ... Ednra(13617)
rat ... Ednra(24326)
Immunogen
synthetic peptide corresponding to the third extracellular domain of human endothelin A receptor, conjugated to KLH. The immunizing peptide has 100% homology with mouse
Application
Anti-Endothelin A Receptor antibody produced in rabbitis suitable for immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 3-16μg/mL using human heart tissue.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Endothelin A Receptor (ETA) is one of three endothelin receptors that mediates the effects of endothelin-1, a vasoconstrictor peptide. Located in the smooth muscle tissue of blood vessels, the interaction between endothelin and ETA plays a role in the regulation of blood pressure. Endothelin receptor type A (ETA, ETAR) is a human G protein-coupled receptor that mediates vasoconstriction of blood vessels. It is involved in tumor cell invasion, survival and metastasis. ETA mediates the promotion of ET-1 on colon cancer cell survival, invasion and MMP-2 expression by a PI3K-mediated mechanism. It plays a critical role in colon cancer metastasis.
Physical form
Solution in phosphate buffered saline containing 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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S Spray et al.
Acta physiologica (Oxford, England), 220(4), 417-431 (2016-11-20)
Delayed cerebral hypoperfusion is a secondary complication found in the days after transient global cerebral ischaemia that worsens the ischaemic damage inflicted by the initial transient episode of global cerebral ischaemia. A recent study demonstrated increased cerebral vasoconstriction in the
Gry Freja Skovsted et al.
Basic & clinical pharmacology & toxicology, 117(5), 297-305 (2015-04-22)
In ischaemic hearts, endothelin (ET) levels are increased, and vasoconstrictor responses to ET-1 are greatly enhanced. We previously reported that ETB receptors are up-regulated in the smooth muscle layer of coronary arteries after myocardial ischaemia-reperfusion and that the MEK-ERK1/2 signalling
H Z Toklu et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 67(2), 205-216 (2016-05-27)
The objective of the study was to determine the effects of a high fat (HF) diet alone or with high fructose (HF/F) on functional and structural changes in the basilar arteries and cardiovascular health parameters in rats. Male Sprague Dawley
Shaolin Nie et al.
Molecular carcinogenesis, 53 Suppl 1, E85-E91 (2013-07-03)
The endothelin (ET)-1/endothelin A receptor (ETAR) axis is reportedly involved in tumor cell invasion, survival, and metastasis. However, the role of ETAR in colon cancer metastasis and the underlying mechanisms have not been defined. In the present study, we assessed
Amanda J Leblanc et al.
Microcirculation (New York, N.Y. : 1994), 20(5), 365-376 (2012-12-04)
The risk for cardiovascular disease increases with advancing age; however, the chronological development of heart disease differs in males and females. The purpose of this study was to determine whether age-induced alterations in responses of coronary arterioles to the endogenous
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