E8909
Phosphodiesterase 3B
recombinant, expressed in Sf9 cells
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Synonym(s):
3′,5′-cyclic-nucleotide phosphodiesterase, PDE 3B
MDL number:
UNSPSC Code:
12352204
NACRES:
NA.54
Recommended Products
recombinant
expressed in Sf9 cells
Quality Level
form
buffered aqueous solution
specific activity
≥1000 units/μg protein
shipped in
dry ice
storage temp.
−70°C
Application
Phosphodiesterase 3B has been used in a study to evaluate the evidence for biological effects of metformin in operable breast cancer. Phosphodiesterase 3B has also been used in a study to investigate the role of intracellular and intercellular communication in perfusion distribution of erythrocyte-derived ATP.
Physical properties
N-terminal GST-tagged 86 kDa protein containing amino acids 592-end
Unit Definition
One unit will convert 1.0 picomole of 3′,5′-cAMP to 5′-AMP per minute at pH 7.4 at 37 °C.
Physical form
Buffered aqueous solution containing Tris-HCl (pH 8.0), NaCl, KCl, Tween-20, DTT, and glycerol
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
新产品
Certificates of Analysis (COA)
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Lin Xie et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 18(4), 444-454 (2011-12-14)
Here we examined whether the expression of a novel immunoregulatory gene set could be used to predict outcomes in murine models of rapamycin-induced cardiac tolerance, spontaneous hepatic tolerance, and cardiac rejection. The expression of the immunoregulatory gene set was assessed
Sirwan Hadad et al.
Breast cancer research and treatment, 128(3), 783-794 (2011-06-10)
Metformin may reduce the incidence of breast cancer and enhance response to neoadjuvant chemotherapy in diabetic women. This trial examined the effects of metformin on Ki67 and gene expression in primary breast cancer. Non-diabetic women with operable invasive breast cancer
Randy S Sprague et al.
Microcirculation (New York, N.Y. : 1994), 19(5), 430-439 (2012-07-11)
In complex organisms, both intracellular and intercellular communication are critical for the appropriate regulation of the distribution of perfusion to assure optimal O(2) delivery and organ function. The mobile erythrocyte is in a unique position in the circulation as it
The cyclic AMP pathway.
Paolo Sassone-Corsi
Cold Spring Harbor perspectives in biology, 4(12), doi:10-doi:10 (2012-12-05)
Mayurranjan S Mitra et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(2), 642-647 (2012-12-26)
Lipin 1 is a coregulator of DNA-bound transcription factors and a phosphatidic acid (PA) phosphatase (PAP) enzyme that catalyzes a critical step in the synthesis of glycerophospholipids. Lipin 1 is highly expressed in adipocytes, and constitutive loss of lipin 1
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