E8531
Ethylenediaminetetra(methylenephosphonic acid)
Synonym(s):
EDTMP, EDTMPA
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About This Item
Empirical Formula (Hill Notation):
C6H20N2O12P4
CAS Number:
Molecular Weight:
436.12
UNSPSC Code:
12352200
EC Number:
215-851-5
InChI key
STNSYZSNIYTNMI-UHFFFAOYSA-N
InChI
1S/C6H20N2O12P4.H3N/c9-21(10,11)3-7(4-22(12,13)14)1-2-8(5-23(15,16)17)6-24(18,19)20;/h1-6H2,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);1H3
Application
Used as a complex with radioactive samarium as a radiopharmaceutical in cancer research. Corrosion inhibitor.
Biochem/physiol Actions
EDTMP is nitrogenous, polyphosphonic acid chelator that complexes with various metal ions.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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J E Bayouth et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 35(1), 63-69 (1994-01-01)
Palliation of bone pain in patients with cancer metastatic to bone is being evaluated in several cancer centers by the administration of the bone-seeking phosphonate ethylenediaminetetramethylenephosphonic acid (EDTMP) chelated with the beta particle-emitting radionuclide 153Sm. In this study, 153Sm-EDTMP was
K Schomäcker et al.
Nuklearmedizin. Nuclear medicine, 32(1), 23-26 (1993-02-01)
It is well known that after application of radioactive complexes for tumour diagnosis or therapy, such as 67Ga-citrate or radiolanthanide complexes (167Tm- or 169Yb-nitrilotriacetate, -citrate, -alpha-hydroxyisobutyrate, 90Y-citrate, etc.) activity is accumulated not only in the tumour but also in other
Sabyasachi Sarkar et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 821(1), 81-87 (2005-05-28)
A matrix developed from N,N,N',N'-ethylenediaminetetramethylenephosphonic acid-modified zirconia beads (further referred to as r_PEZ); 25-38 microm in diameter and with a pore size of 22+/-3 nm, was utilized for the separation of immunoglobulins (Igs). r_PEZ has been shown to bind to
Radionuclide targeting of bone metastases: which efficacy?
S Leyvraz et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 8(9), 1598-1599 (1990-09-01)
G J Beyer et al.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology, 19(2), 201-203 (1992-02-01)
The influence of the ligands ethylenediaminetetramethylene phosphonic acid (EDTMP) and citrate (CIT) on the biodistribution of radio-yttrium in rats bearing a DS-carcinosarcoma was compared. 88Y-EDTMP and 87Y-CIT were i.v. injected into the same animals. Faster blood clearance and higher renal
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