Skip to Content
Merck
CN
All Photos(1)

Key Documents

Safety Information

E8531

Sigma-Aldrich

Ethylenediaminetetra(methylenephosphonic acid)

Synonym(s):

EDTMP, EDTMPA

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C6H20N2O12P4
CAS Number:
1429-50-1
Molecular Weight:
436.12
EC Number:
215-851-5
UNSPSC Code:
12352200

InChI

1S/C6H20N2O12P4.H3N/c9-21(10,11)3-7(4-22(12,13)14)1-2-8(5-23(15,16)17)6-24(18,19)20;/h1-6H2,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20);1H3

InChI key

STNSYZSNIYTNMI-UHFFFAOYSA-N

Application

Used as a complex with radioactive samarium as a radiopharmaceutical in cancer research. Corrosion inhibitor.

Biochem/physiol Actions

EDTMP is nitrogenous, polyphosphonic acid chelator that complexes with various metal ions.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
070M1929
050M1320
020M1429
108K1165

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

G J Beyer et al.
Nuclear medicine and biology, 24(5), 367-372 (1997-07-01)
High-resolution gamma spectroscopy was applied to measure simultaneously the biodistribution of carrier-free radionuclides of several lanthanides (141Ce, 145Sm, 149Gd, 167Tm) and 225Ac in tumor-bearing nude mice. Mixtures of the radiotracers were injected in solutions containing different concentrations of EDTMP (ethylenediaminetetramethylenephosphonic
Y Tanaka et al.
Shigaku = Odontology; journal of Nihon Dental College, 78(3), 575-591 (1990-10-01)
Dose dependent effects of EDTPO on morphology and mineralization of hard tissues as well as calcium (Ca), inorganic phosphorus (IP) and alkaline phosphatase (ALP) levels in serum were examined in growing rats. Five groups of male S.D. rats weighing 110-120g
Stefan Toegel et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 68(2), 406-412 (2007-07-06)
The present study aimed to develop convenient preparation and quality control protocols for [(68)Ga]-EDTMP, a potential radiotracer for skeletal PET imaging. Furthermore, bone binding characteristics with special focus on the influence of carrier addition were evaluated. No-carrier-added (nca), carrier-added and
M Láznícek et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 45(9), 949-953 (1994-09-01)
The pharmacokinetics and elimination of EDTMP chelates with different radionuclides (99mTc, 111In and 153Sm) has been investigated in rats. The biodistribution of the complexes under study was similar and two main processes, namely bone uptake and the elimination of glomerular
J C Lattimer et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 31(8), 1316-1325 (1990-08-01)
Forty dogs with spontaneous skeletal neoplasia were treated with 153Sm-EDTMP (ethylenediaminetetramethylene phosphonic acid). Both primary and metastatic lesions were treated. Two treatment regimes, a single (37 MBq (1.0 mCi)/kg dose or two 37 MBq (1.0 mCi)/kg doses separated by 1
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service