All Photos(1)
Synonym(s):
2-(4-Fluorobenzoylamino)benzoic acid methyl ester, 2-(4-Fluorobenzoylamino)methylbenzoate
Empirical Formula (Hill Notation):
C15H12NFO3
CAS Number:
Molecular Weight:
273.26
MDL number:
UNSPSC Code:
12352203
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
solid
solubility
DMSO: soluble 19 mg/mL
SMILES string
COC(=O)c1ccccc1NC(=O)c2ccc(F)cc2
InChI
1S/C15H12FNO3/c1-20-15(19)12-4-2-3-5-13(12)17-14(18)10-6-8-11(16)9-7-10/h2-9H,1H3,(H,17,18)
InChI key
KIAPWMKFHIKQOZ-UHFFFAOYSA-N
Application
Exo 1 has been used as a component of the BRB80 buffer to study coat protein 1 (COPI)-mediated membrane trafficking. It has also been used as a Golgi inhibitor to study its effects on the long interspersed nuclear element-1 (L1) retrotransposition.
Biochem/physiol Actions
Exo 1 is a cell-permeable methylanthranilate analog that promotes the release of adenosine diphosphate (ADP)-ribosylation factor (ARF) 1 from Golgi membranes. It also inhibits the membrane trafficking between the endoplasmic reticulum (ER) and the Golgi bodies.
Reversible inhibitor of exocytosis; Golgi ARF 1 (ADP-Ribosylation Factor) GTPase activator.
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Philip J Lester et al.
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CRISPR gene drives have potential for widespread and cost-efficient pest control, but are highly controversial. We examined a potential gene drive targeting spermatogenesis to control the invasive common wasp (Vespula vulgaris) in New Zealand. Vespula wasps are haplodiploid. Their life
ALan F Rees et al.
Marine biology, 164(2), 30-30 (2017-01-31)
Many marine megavertebrate taxa, including sea turtles, disperse widely from their hatching or birthing locations but display natal homing as adults. We used flipper tagging, satellite tracking and genetics to identify the origin of loggerhead turtles living in Amvrakikos Gulf
Time-lapse observation of chromosomes, cytoskeletons and cell organelles during male meiotic divisions in Drosophila
Tanabe K, et al.
Bio-protocol, 7, e2225-e2225 (2017)
Yan Feng et al.
Proceedings of the National Academy of Sciences of the United States of America, 100(11), 6469-6474 (2003-05-10)
A phenotypic screen was used to search for drug-like molecules that can interfere with specific steps in membrane traffic. 2-(4-Fluorobenzoylamino)-benzoic acid methyl ester (Exo1), identified in this screen, induces a rapid collapse of the Golgi to the endoplasmic reticulum, thus
Justin Chun et al.
Molecular biology of the cell, 19(8), 3488-3500 (2008-06-06)
Despite extensive work on ADP-ribosylation factor (Arf) 1 at the Golgi complex, the functions of Arf2-5 in the secretory pathway, or for that of any Arf at the ER-Golgi intermediate compartment (ERGIC) remain uncharacterized. Here, we examined the recruitment of
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