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Merck
CN

E8031

Esmolol hydrochloride

≥98% (HPLC), β1 adrenoceptor antagonist , solid

Synonym(s):

4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzenepropanoic acid methyl ester hydrochloride hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C16H26NClO4
CAS Number:
81161-17-3
Molecular Weight:
331.83
UNSPSC Code:
12352200
PubChem Substance ID:
329799075
NACRES:
NA.77
MDL number:
MFCD00941432

Key Documents

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Product Name

Esmolol hydrochloride, ≥98% (HPLC), solid

SMILES string

Cl.COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1

InChI

1S/C16H25NO4.ClH/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3;/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3;1H

InChI key

GEKNCWBANDDJJL-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

mp

89.0-90.6 °C

solubility

H2O: 12 mg/mL

originator

Baxter

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ADRB1(153), ADRB2(154)

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Related Categories

Features and Benefits

This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Application

Esmolol hydrochloride (ESM) may be used as a standard in spectrophotometric and electrochemical method for the determination of ESM in biological samples and pharmaceutical formulations.

Biochem/physiol Actions

Esmolol hydrochloride (ESM) is a class II antiarrhythmic drug. It is used to decrease the force and rate of heart contractions during surgery. Overdose of ESM can lead to side effects such as bradycardia, cardiac arrest, hypoventilation, mood disorder, and coma.
Esmolol hydrochloride is a ultrashort-acting β1 adrenoceptor antagonist (β1 receptor occupancy = 84.7%).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000463574
0000463574
0000445438
0000445438
0000441966

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Electrochemical System for Determination of Esmolol Hydrochloride Using Square Wave Adsorptive Stripping Voltammetry
Alarfaj NA and El-Tohamy MF
International Journal of Electrochemical Science (2016)
George Dimopoulos et al.
The Journal of surgical research, 198(1), 175-184 (2015-06-16)
Based on previous animal studies showing promising immunomodulatory efficacy esmolol, a selective β1-blocker, it was assumed that administration of esmolol in experimental pyelonephritis by multidrug-resistant Pseudomonas aeruginosa would prolong survival and modulate immune response. Acute pyelonephritis was induced in 80
Spectrophotometric determination of esmolol hydrochloride using analytical reagents
Narayana A, et al.
Indian Journal of Advances in Chemical Science null
Yong-Feng Zhu et al.
Journal of laparoendoscopic & advanced surgical techniques. Part A, 25(11), 903-907 (2015-11-18)
To determine the effect of lavage with adrenaline solution on CO2 absorption during retroperitoneal laparoscopic surgery. Sixty patients scheduled to undergo retroperitoneal laparoscopic surgery were divided into an AD group (lavage with normal saline containing adrenaline [1:500,000], n = 30)

Articles

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