E7404
Microsomal Epoxide Hydrolase
from human, recombinant, expressed in human lymphoblast cell line
Synonym(s):
Xenobiotic Epoxide Hydrolase, Epoxide Hydratase, mEH
biological source
human
recombinant
expressed in human lymphoblast cell line
form
buffered aqueous solution (100 mM potassium phosphate, pH 7.4)
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... EPHX1(2052)
Application
Microsomal epoxide hydrolase has been used in a study to assess its activation of microsomal epoxide hydrolase by interaction with cytochromes P450. Microsomal epoxide hydrolase has also been used in a study to investigate the possible role of its gene polymorphism as a risk factor for developing insulin resistance and type 2 diabetes mellitus.
Other Notes
Epoxide hydrolase functions to render epoxides less chemically reactive. Two forms of human hydrolase are involved in this process, microsomal epoxide hydrolase (mEH) and soluble epoxide hydrolase. mEH is an enzyme of the endoplasmic reticulum. Although typically expressed in the liver, it is also present at significant levels in other tissues such as the adrenal gland. The primary characteristics of mEH substrates include marked lipophilicity and a lack of any trans-substitutions on the oxirane ring.
Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Rakesh Ghosh et al.
Mutation research, 749(1-2), 80-86 (2013-05-08)
Studies have reported gene-by-environment interaction for chronic respiratory conditions but none on acute illnesses in children. We investigated, longitudinally, whether genotype modifies the relationship of environmental exposures (second-hand tobacco smoke, polycyclic aromatic hydrocarbons, particulate matter <2.5μm (PM2.5)) with acute bronchitis
Possible role of microsomal epoxide hydrolase gene polymorphism as a risk factor for developing insulin resistance and type 2 diabetes mellitus.
Ghattas, M. and M. Amer.
Endocrine J., doi :10-doi :10 (2012)
Chen-Yang Duan et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(1), 659-666 (2013-08-21)
Previous studies have focused on the association of a gene (EPHX1) encoding microsomal epoxide hydrolase with the carcinogenesis of hepatocellular carcinoma (HCC). In the present study, we performed a meta-analysis to systematically summarize the possible association between EPHX1 genetic polymorphisms
Activation of microsomal epoxide hydrolase by interaction with cytochromes P450: kinetic analysis of the association and substrate-specific activation of epoxide hydrolase function.
Taura Ki K, Yamada H
Archives of Biochemistry and Biophysics, 402(2), 275-280 (2012)
Danuta Mielzynska-Svach et al.
Mutagenesis, 28(5), 591-599 (2013-07-23)
This article is a follow-up to our previous molecular epidemiology studies on the DNA damage in children from the Upper Silesia region of Poland. It is expected that metabolic and DNA repair gene polymorphisms may modulate individual susceptibility to environmental
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