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Safety Information

E6375

Sigma-Aldrich

Estriol 3-sulfate sodium salt

≥98% (TLC)

Synonym(s):

1,3,5(10)-Estratriene-3,16α,17β-triol 3-sulfate, 3,16α,17β-Trihydroxy-1,3,5(10)-estratriene 3-sulfate

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About This Item

Linear Formula:
C18H23O6SNa
CAS Number:
5150-64-1
Molecular Weight:
390.43
MDL number:
MFCD00056547
UNSPSC Code:
12171500
PubChem Substance ID:
24894625
NACRES:
NA.47
form:
powder
Assay:
≥98% (TLC)

Quality Level

200

Assay

≥98% (TLC)

form

powder

contains

~30% methylglucamine as stabilizer

solubility

methanol: 19.60-20.40 mg/mL, clear, colorless to faintly yellow

application(s)

diagnostic assay manufacturing
hematology
histology

shipped in

ambient

storage temp.

room temp

SMILES string

[Na].[H][C@]12CC[C@]3(C)[C@@H](O)[C@H](O)C[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24

InChI

1S/C18H24O6S.Na.H/c1-18-7-6-13-12-5-3-11(24-25(21,22)23)8-10(12)2-4-14(13)15(18)9-16(19)17(18)20;;/h3,5,8,13-17,19-20H,2,4,6-7,9H2,1H3,(H,21,22,23);;/t13-,14-,15+,16-,17+,18+;;/m1../s1

InChI key

NGMCHEUPKPRHNC-XZEIGEQDSA-N

Related Categories

Packaging

Package size based on steroid content

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P281

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000329443
0000329443
0000290559
0000269817
0000223612

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T Tanaka et al.
Steroids, 63(10), 516-522 (1998-11-04)
A facile and sensitive chemiluminescence enzyme-linked immunosorbent assay (ELISA) of estriol 3-sulfate using a bridge-heterologous system was established. 6 alpha-Hydroxyestriol 3-sulfate 6-hemisuccinate was synthesized as a novel hapten. Antisera were raised in male guinea-pigs against 6 alpha-hydroxyestriol 3-sulfate 6-hemisuccinate-bovine serum
J R Pasqualini et al.
Annals of the New York Academy of Sciences, 595, 106-116 (1990-01-01)
Different estrogen-3-sulfates (estrone-3-sulfate, estradiol-3-sulfate, and estriol-3-sulfate) can provoke important biologic responses in different mammary cancer cell lines; there is a significant increase in progesterone receptor. However, no significant effect was observed with estrogen-17-sulfates. The reason for the biologic response of
J R Pasqualini et al.
European journal of cancer & clinical oncology, 22(12), 1495-1501 (1986-12-01)
The R-27 cell line is a variant clone derived from the MCF-7 human breast cancer cell line which has lost its inhibitory response to anti-estrogens. In the present study, we have compared the biological responses to estriol (E3), estriol-3-sulfate (E3-3-S)
T Tanaka et al.
Steroids, 46(1), 649-657 (1985-07-01)
A highly specific anti-estriol 3-sulfate antiserum was treated with 50% ammonium sulfate, and the crude globulin fraction was coupled to CNBr-activated Sepharose-4B. Addition of 0.1M Tris-HC1 buffer (pH 8.3) containing 0.1M glutamine to the solution of antigen-antibody enabled assaying without
J R Pasqualini et al.
Journal of steroid biochemistry, 20(4B), 1047-1055 (1984-04-01)
The biological responses of estriol (E3) and of estriol-3-sulfate (E3-S) in the fetal and newborn uteri of guinea pig were studied. After a treatment of E3 (1 mg/kg/day) or E3-S (1.4 mg/kg/day) to pregnant guinea pigs (49-60 days of gestation)
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