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E5627

Erythropoietin human

recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture, ~100,000 units/mg protein

Synonym(s):

EPO

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About This Item

CAS Number:
11096-26-7
UNSPSC Code:
51111800
EC Number:
234-317-2
NACRES:
NA.32
MDL number:
MFCD00131025

Key Documents

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Product Name

Erythropoietin human, recombinant, expressed in CHO cells, lyophilized powder, suitable for cell culture, ~100,000 units/mg protein

biological source

human

recombinant

expressed in CHO cells

form

lyophilized powder

specific activity

~100,000 units/mg protein

packaging

pkg of 10UN

technique(s)

cell culture | mammalian: suitable

color

white

UniProt accession no.

P01588

storage temp.

−20°C

Quality Level

200

Gene Information

human ... EPO(2056), EPOR(2057)

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Analysis Note

The biological activity is assayed in tissue culture using mouse fetal liver cells.

Application

Erythropoietin human has been used:
  • as a component of cardiac stem cell medium
  • to test its neuroprotective effect on diabetic mice
  • to test its effect on hippocampal synapses in mice

Biochem/physiol Actions

Erythropoietin (EPO) elicits antiapoptotic, anti-inflammatory and tissue protective functions. EPO is essential for maintaining red blood progenitor cells. It is used for treating hematological disorders and in perioperative therapies. A homozygous mutation in EPO gene obstructs its interaction with receptor and the signaling cascade resulting in severe anemia. Elevated levels of EPO due to mutations is implicated in the pathogenesis of familial erythrocytosis.
Erythropoietin is a glycoprotein that is the principal regulator of red blood cell growth and differentiation.

General description

Erythropoietin is a glycoprotein cytokine and hormone and belongs to the type I cytokine superfamily. It undergoes posttranslational modifications and exists as 18 and 30 kDa molecular weight forms. It is mapped to human chromosome 7q22.

Physical form

Lyophilized as 10 units EPO, 10 mg trisodium citrate and 10 mg NaCl at pH ≅7.0.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBQ4564V
SLBK8322V
SLBK6398V
SLBJ3192V
SLBH3935V

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Concurrent isolation of 3 distinct cardiac stem cell populations from a single human heart biopsy
Monsanto MM, et al.
Circulation Research, 121(2), 113-124 (2017)
A distinct region in erythropoietin that induces immuno/inflammatory modulation and tissue protection
Yuan RR, et al.
Neurotherapeutics, 12(4), 850-861 (2015)
Recombinant erythropoietin in clinical practice
Ng T, et al.
Postgraduate Medical Journal, 79(933), 367-376 (2003)
Functional selectivity in cytokine signaling revealed through a pathogenic EPO mutation
Kim AR, et al.
Cell, 168(6), 1053-1064 (2017)
Erythropoietin Protects Against Cognitive Impairment and Hippocampal Neurodegeneration in Diabetic Mice
Othman M, et al.
Behavioral Sciences, 9(1), 4-4 (2019)
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