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E5391

Sigma-Aldrich

Ethylenediaminetetraacetic acid tetrasodium salt hydrate

≥99.0%

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Synonym(s):
EDTA tetrasodium salt, Edathamil, Tetrasodium ethylenediaminetetraacetate hydrate
Linear Formula:
(NaOOCCH2)2NCH2CH2N(CH2COONa)2 · xH2O
CAS Number:
194491-31-1
Molecular Weight:
380.17 (anhydrous basis)
Beilstein:
3861753
EC Number:
200-573-9
MDL number:
MFCD00150025
UNSPSC Code:
12352204
PubChem Substance ID:
24894613
NACRES:
NA.83

biological source

synthetic (organic)

Quality Level

200

Assay

≥99.0%

form

powder

technique(s)

ligand binding assay: suitable

impurities

Insoluble matter, passes filter test

pH

11.0-12.0 (0.1 M in H2O)

solubility

H2O: 0.1 M, clear, colorless

anion traces

chloride (Cl-): ≤0.05%
sulfate (SO42-): ≤0.01%

cation traces

Al: ≤0.001%
As: ≤0.0001%
Ba: ≤0.0005%
Bi: ≤0.0005%
Ca: <0.001%
Cd: ≤0.0005%
Co: ≤0.0005%
Cr: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.0005%
Li: ≤0.0005%
Mg: ≤0.0005%
Mn: ≤0.0005%
Mo: ≤0.0005%
Ni: ≤0.0005%
Pb: ≤0.0005%
Sr: ≤0.0005%
Zn: ≤0.0005%

absorption

≤0.06 at 280 in H2O at 0.1 M
≤1.5 at 260 in H2O at 0.1 M

application(s)

sample preparation

storage temp.

room temp

SMILES string

O.[Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

1S/C10H16N2O8.4Na.H2O/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;;;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;;;;1H2/q;4*+1;/p-4

InChI key

GXFFSKMBMYHTAE-UHFFFAOYSA-J

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Application

EDTA is an inhibitor of metalloproteases, at effective concentrations of 1-10 mM. EDTA acts as a chelator of the zinc ion in the active site of metalloproteases, and can also inhibit other metal ion-dependent proteases such as calcium-dependent cysteine proteases. For use as an anticoagulant, disodium or tripotassium salts of EDTA are most commonly used. The optimal concentration is 1.5 mg per ml of blood.

Preparation Note

Soluble in water at room temperature up to 1.45 M. The pH of this solution will be approximately 10 to 11 and will be rather viscous.

Signal Word

Danger

Hazard Statements

H302 + H332,H318,H373

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - STOT RE 2

Target Organs

Respiratory Tract

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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