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Merck
CN

E5017

Anti-LPA1, C-Terminal antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-EDG-2, Anti-Endothelial Cell Differentiation Gene 2

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD02686119
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human, rat
Citations:
2
Technique(s):
western blot: suitable
Uniprot accession no.:
Q92633

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Product Name

Anti-LPA1, C-Terminal antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

biological source

rabbit

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

human, rat

technique(s)

western blot: suitable

UniProt accession no.

Q92633

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

200

Gene Information

human ... LPAR1(1902)
rat ... Lpar1(116744)

Related Categories

Physical form

Solution in PBS with 0.08% sodium azide

Application

Anti-LPA1, C-Terminal antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat brain microsomal fraction.

Biochem/physiol Actions

Lysophosphatidic acid receptor 1 (LPA1) is a protein encoded by the LPAR1 gene in humans. It is constitutively localized in the nucleus of mammalian cells and may be involved in regulating intranuclear protein phosphorylation and signalling. LPA1 is differentially expressed in androgen-insensitive and LPA-responsive cells. It is not expressed in androgen-dependent and LPA-resistant cells.Its expression is significantly higher in the cancer compared with the benign tissues and may possibly act as a drug target to interfere with progression of prostate cancer. LPA1 helps in promoting cell proliferation, survival and migration by acting on cognate G protein-coupled receptors.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Immunogen

synthetic peptide corresponding to amino acids 328-344 of human EDG-2/LPA1.

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Storage Class

10 - Combustible liquids

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLCJ8565
SLCL1178
SLBN4130
079K1215
045K0858

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Catherine M Waters et al.
The Biochemical journal, 398(1), 55-62 (2006-05-24)
We show that LPA1 (lysophosphatidic acid receptor-1) is constitutively localized in the nucleus of mammalian cells. LPA1 also traffics from cell membranes to the nucleus in response to LPA (lysophosphatidic acid). Several lines of evidence suggest an important role for
Rishu Guo et al.
Endocrinology, 147(10), 4883-4892 (2006-07-01)
The bioactive phospholipid lysophosphatidic acid (LPA) promotes cell proliferation, survival, and migration by acting on cognate G protein-coupled receptors named LPA(1), LPA(2), and LPA(3). We profiled gene expression of LPA receptors in androgen-dependent and androgen-insensitive prostate cancer cells and found

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