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Key Documents

Safety Information

E4392

Sigma-Aldrich

Echinomycin

90-95%

Synonym(s):

Quinomycin A

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About This Item

Empirical Formula (Hill Notation):
C51H64N12O12S2
CAS Number:
Molecular Weight:
1101.26
Beilstein:
78671
MDL number:
UNSPSC Code:
51101500
PubChem Substance ID:

Assay

90-95%

Mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

CS[C@H]1SC[C@@H]2N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@H](C(C)C)N(C)C2=O)NC(=O)c3cnc4ccccc4n3)NC(=O)c5cnc6ccccc6n5

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General description

Chemical structure: peptide

Biochem/physiol Actions

Powerful antimicrobial and antitumor agent; selectively inhibits nucleic acid synthesis in vitro. Binds to DNA by a bifunctional mode of intercalation.

Other Notes

A cyclodepsipeptide antibiotic with quinoxaline functionality

Pictograms

Health hazardSkull and crossbones

Signal Word

Danger

Hazard Statements

Precautionary Statements

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2

Storage Class Code

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Echinomycin: a bifunctional intercalating antibiotic.
M J Waring et al.
Nature, 252(5485), 653-657 (1974-12-20)

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