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Merck
CN

E4392

Echinomycin

90-95%

Synonym(s):

Quinomycin A

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About This Item

Empirical Formula (Hill Notation):
C51H64N12O12S2
CAS Number:
512-64-1
Molecular Weight:
1101.26
PubChem Substance ID:
24894552
UNSPSC Code:
51101500
MDL number:
MFCD00156105
Beilstein/REAXYS Number:
78671

Key Documents

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SMILES string

CS[C@H]1SC[C@@H]2N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1N(C)C(=O)[C@H](C)NC(=O)[C@@H](COC(=O)[C@H](C(C)C)N(C)C2=O)NC(=O)c3cnc4ccccc4n3)NC(=O)c5cnc6ccccc6n5

assay

90-95%

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

General description

Chemical structure: peptide

Biochem/physiol Actions

Powerful antimicrobial and antitumor agent; selectively inhibits nucleic acid synthesis in vitro. Binds to DNA by a bifunctional mode of intercalation.

Other Notes

A cyclodepsipeptide antibiotic with quinoxaline functionality

pictograms

Health hazardSkull and crossbones
GHS08,GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Repr. 2

Storage Class

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
023H4057

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Echinomycin: a bifunctional intercalating antibiotic.
M J Waring et al.
Nature, 252(5485), 653-657 (1974-12-20)
K R Fox et al.
Nucleic acids research, 18(8), 1957-1963 (1990-04-25)
DNA fragments containing the sequence CG(AT)nCG have been used in footprinting experiments to assess the effect of echinomycin, which binds to CG steps, on the structure of the central AT region. DNAase I normally cuts ApT much better than TpA;

Related Content

Product Information Sheet - E4392

Product Information Sheet

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