E4267
9-Ethylguanine
Synonym(s):
2-Amino-9-ethyl-6-hydroxypurine, 6-Amino-9-ethyl-2-hydroxypurine, 9-EtG
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About This Item
Empirical Formula (Hill Notation):
C7H9N5O
CAS Number:
Molecular Weight:
179.18
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥98%
Form:
powder
Solubility:
1 M NaOH: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
Storage temp.:
2-8°C
InChI key
WDOYBEPLTCFIRQ-UHFFFAOYSA-N
SMILES string
CCn1cnc2C(=O)N=C(N)Nc12
InChI
1S/C7H9N5O/c1-2-12-3-9-4-5(12)10-7(8)11-6(4)13/h3H,2H2,1H3,(H3,8,10,11,13)
assay
≥98%
form
powder
solubility
1 M NaOH: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
storage temp.
2-8°C
Quality Level
Application
9-Ethylguanine (9-EtG) is used as a DNA model base for a variety of physical chemical studies of organometallic complexes.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Eva Corral et al.
Inorganic chemistry, 46(16), 6715-6722 (2007-07-10)
The binding capability of three ruthenium polypyridyl compounds of structural formula [Ru(apy)(tpy)Ln-](ClO4)(2-n) [1a-c; apy = 2,2'-azobis(pyridine), tpy = 2,2':6',2''-terpyridine, L = Cl, H2O, CH3CN] to a fragment of DNA was studied. The interaction between each of these complexes and the
Sudeshna Roy et al.
Dalton transactions (Cambridge, England : 2003), 48(48), 10846-10860 (2009-12-22)
The reaction of the redox-active ligand, Hpyramol (4-methyl-2-N-(2-pyridylmethyl)aminophenol) with K(2)PtCl(4) yields monofunctional square-planar [Pt(pyrimol)Cl], PtL-Cl, which was structurally characterised by single-crystal X-ray diffraction and NMR spectroscopy. This compound unexpectedly cleaves supercoiled double-stranded DNA stoichiometrically and oxidatively, in a non-specific manner
Ganna V Kalayda et al.
Journal of medicinal chemistry, 48(16), 5191-5202 (2005-08-05)
The dinuclear platinum complexes with aliphatic diamines [{cis-Pt(NH(3))(2)Cl}(2)(mu-H(2)N(CH(2))(6)NH(2))](NO(3))(2) (1,1/c,c) and [{trans-Pt(NH(3))(2)Cl}(2)(mu-H(2)N(CH(2))(4)NH(2))](NO(3))(2) (1,1/t,t), which are known to be highly active in vitro against several cancer cell lines, have been modified with a fluorogenic reporter (carboxyfluorescein diacetate, CFDA) and a hapten (dinitrophenyl
Flavia Barragán et al.
Journal of the American Chemical Society, 133(35), 14098-14108 (2011-07-30)
A photoactivated ruthenium(II) arene complex has been conjugated to two receptor-binding peptides, a dicarba analogue of octreotide and the Arg-Gly-Asp (RGD) tripeptide. These peptides can act as "tumor-targeting devices" since their receptors are overexpressed on the membranes of tumor cells.
Sudeshna Roy et al.
Journal of inorganic biochemistry, 103(9), 1278-1287 (2009-08-07)
Two chelating ligands based on secondary amines have been selected to prepare four new Pt(II) compounds. The ligands bis(pyridine-2-yl)amine, abbreviated dpa, and bis(pyrimidine-2-yl)amine, abbreviated dipm, are chosen to design a rigid chelating motif to allow the study of subtle differences
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