E3149
S-Ethylisothiourea hydrobromide
≥98%
Synonym(s):
2-Ethyl-2-thiopseudourea hydrobromide
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About This Item
Empirical Formula (Hill Notation):
C3H8N2S · HBr
CAS Number:
Molecular Weight:
185.09
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
Recommended Products
Assay
≥98%
storage temp.
2-8°C
SMILES string
Br[H].CCSC(N)=N
Biochem/physiol Actions
Inhibitor of inducible human, endothelial and neuronal nitric oxide synthetase isozymes.
Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
188.6 °F - Solvent
Flash Point(C)
87 °C - Solvent
Regulatory Information
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G J Southan et al.
British journal of pharmacology, 114(2), 510-516 (1995-01-01)
1. The induction of a calcium-independent isoform of nitric oxide (NO) synthase (iNOS) and a subsequent enhanced formation of NO has been implicated in the pathophysiology of a variety of diseases including inflammation and circulatory shock. Here we demonstrate that
E P Garvey et al.
The Journal of biological chemistry, 269(43), 26669-26676 (1994-10-28)
S-Ethylisothiourea was a potent competitive inhibitor of human nitric oxide synthase (NOS), with Ki values of 17, 36, and 29 nM for the inducible (i), endothelial (e), and neuronal (n) isozymes, respectively. Unlike some potent inhibitors of NOS, no time
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