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Merck
CN

E2535

Eprosartan mesylate

≥98% (HPLC)

Synonym(s):

Eprosartan Monomethanesulfonate, SKF-108566J, Teveten

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About This Item

Empirical Formula (Hill Notation):
C23H24N2O4S · CH4O3S
CAS Number:
144143-96-4
Molecular Weight:
520.62
NACRES:
NA.77
PubChem Substance ID:
329799032
UNSPSC Code:
12352200
MDL number:
MFCD08141807

Key Documents

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Product Name

Eprosartan mesylate, ≥98% (HPLC)

InChI

1S/C23H24N2O4S.CH4O3S/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27;1-5(2,3)4/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29);1H3,(H,2,3,4)/b18-12+;

SMILES string

CS(O)(=O)=O.CCCCc1ncc(\C=C(/Cc2cccs2)C(O)=O)n1Cc3ccc(cc3)C(O)=O

InChI key

DJSLTDBPKHORNY-XMMWENQYSA-N

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >10 mg/mL

originator

Abbott

storage temp.

room temp

Quality Level

100
200

Gene Information

human ... AGTR1(185)

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Biochem/physiol Actions

Angiotensin II type 1 (AT1) receptor antagonist; anti-hypertensive.

Features and Benefits

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000158706
0000158705
0000158706
0000153714
0000153714

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Wilco de Jager et al.
BMC immunology, 10, 52-52 (2009-09-30)
Growing knowledge about cellular interactions in the immune system, including the central role of cytokine networks, has lead to new treatments using monoclonal antibodies that block specific components of the immune system. Systemic cytokine concentrations can serve as surrogate outcome
Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation.
Lee, et al.
Experimental & Molecular Medicine, 55, 910-925 (2023)

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