Skip to Content
Merck
CN
All Photos(1)

Documents

Safety Information

E1279

Sigma-Aldrich

Enoximone

solid

Synonym(s):

1,3-Dihydro-4-methyl-5-(4-methylthiobenzoyl)-2H-imidazol-2-one

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C12H12N2O2S
CAS Number:
77671-31-9
Molecular Weight:
248.30
MDL number:
MFCD00867130
UNSPSC Code:
41106305
PubChem Substance ID:
24278408
NACRES:
NA.77

form

solid

Quality Level

100

color

light yellow

solubility

DMSO: soluble 28 mg/mL

SMILES string

CSc1ccc(cc1)C(=O)C2=C(C)NC(=O)N2

InChI

1S/C12H12N2O2S/c1-7-10(14-12(16)13-7)11(15)8-3-5-9(17-2)6-4-8/h3-6H,1-2H3,(H2,13,14,16)

InChI key

ZJKNESGOIKRXQY-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139) , PDE3B(5140)

Biochem/physiol Actions

Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Antje Hönisch et al.
Basic research in cardiology, 105(2), 155-167 (2009-10-21)
Reperfusion injury is strongly involved in the loss of functional heart tissue in patients after acute myocardial infarction. Various signal transduction pathways to reduce infarct size during reperfusion have been characterized. However, so far in the clinical setting no standard
Use of oral enoximone in pharmacologic bridging to cardiac transplantation.
M R Bristow
Zeitschrift fur Kardiologie, 83 Suppl 2, 15-19 (1994-01-01)
Stijn Schauvliege et al.
Veterinary anaesthesia and analgesia, 36(2), 101-109 (2009-02-26)
To investigate the influence of calcium chloride (CaCl(2)) on the cardio-respiratory effects of enoximone in isoflurane anaesthetized ponies. Prospective consecutive experimental trial. Animals Six healthy ponies, weighing 287 +/- 55 kg were included in this study. After sedation (romifidine, 80
M W Vernon et al.
Drugs, 42(6), 997-1017 (1991-12-01)
Enoximone is an imidazolone derivative currently undergoing trials in patients with congestive heart failure refractory to conventional therapy. It is a phosphodiesterase inhibitor with both positive inotropic and vasodilator properties, and is active by both oral and intravenous routes of
R C Dage et al.
Cardiology, 77 Suppl 3, 2-13 (1990-01-01)
Enoximone is an inotropic vasodilating agent. Its principal effects are positive inotropism and vasodilation, which are not accompanied by changes in myocardial oxygen consumption. An inotropic dose of enoximone increases the level of cyclic AMP in the isolated, blood-perfused dog
View All Related Papers

Articles

Discover Bioactive Molecules for Nucleotides

Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service