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Merck
CN

E0761

Ebelactone A microbial

esterase inhibitor

Synonym(s):

3,11-Dihydroxy-2,4,6,8,10,12-hexamethyl-9-oxo-6-tetradecenoic acid 1,3-lactone

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About This Item

Empirical Formula (Hill Notation):
C20H34O4
CAS Number:
76808-16-7
Molecular Weight:
338.48
NACRES:
NA.77
PubChem Substance ID:
24894373
UNSPSC Code:
12352202
MDL number:
MFCD00036710

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InChI

1S/C20H34O4/c1-8-12(3)17(21)15(6)18(22)13(4)9-11(2)10-14(5)19-16(7)20(23)24-19/h9,12-17,19,21H,8,10H2,1-7H3/b11-9+/t12-,13-,14+,15+,16+,17-,19+/m1/s1

SMILES string

[H][C@@]1([C@H](C/C(C)=C/[C@H](C([C@H]([C@@H]([C@@H](CC)C)O)C)=O)C)C)OC([C@H]1C)=O

InChI key

WOISDAHQBUYEAF-QIQXJRRPSA-N

biological source

Streptomyces sp.

assay

≥98% (HPLC)

form

powder

solubility

methanol: 10 mg/mL, clear, colorless

storage temp.

2-8°C

Quality Level

100

General description

Esterase inhibitors produced by Streptomyces sp. MG7-G1 strain

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX7876
MKCP5578
MKCL2829
MKCJ1250
MKCH0498

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Gianfranco De Pascale et al.
The Journal of antibiotics, 64(7), 483-487 (2011-04-28)
Homoserine transacetylase (HTA) catalyzes the transfer of an acetyl group from acetyl-CoA to the hydroxyl group of homoserine. This is the first committed step in the biosynthesis of methionine (Met) from aspartic acid in many fungi, Gram-positive and some Gram-negative
I A Hoskins et al.
American journal of obstetrics and gynecology, 163(6 Pt 1), 1944-1947 (1990-12-01)
Assessment of leukocyte esterase activity in amniotic fluid for the rapid and reliable diagnosis of chorioamnionitis has been demonstrated previously. We compared in vitro inhibition of esterase activity in amniotic fluid with bacterial cultures to identify the origins of the
S Banerjee et al.
Cancer research, 51(4), 1092-1098 (1991-02-15)
Levels of estradiol 17 beta-ester hydrolytic activity in the breast cyst fluid (BCF) from 25 different women with fibrocystic disease of the breast were found to vary over a wide range (0-2.4 nmol/min/mg protein for estradiol acetate). On the basis
Low-molecular-weight immunomodifiers produced by micro-organisms.
H Umezawa
Biotechnology & genetic engineering reviews, 3, 255-273 (1985-01-01)
A Scaloni et al.
The Journal of biological chemistry, 269(21), 15076-15084 (1994-05-27)
The presence of a cysteine residue(s) near the active site of acylpeptide hydrolase was suggested by inactivation of the enzyme with sulfhydryl-modifying agents and by the substantial protection against inactivation afforded by the competitive inhibitor acetylmethionine. 5,5'-dithiobis-(2-nitrobenzoate) titrations of the
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