D9570
Dothiepin hydrochloride
≥98% (HPLC)
Synonym(s):
3-Dibenzo[b,e]thepin-11(6H)-ylidine-N,N-dimethyl-1-propanamine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C19H21NS·HCl
CAS Number:
Molecular Weight:
331.90
UNSPSC Code:
12352200
EC Number:
212-978-8
InChI key
XUPZAARQDNSRJB-CULRIWENSA-N
InChI
1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;
assay
≥98% (HPLC)
form
solid
solubility
DMSO: ≥26 mg/mL
storage temp.
room temp
Biochem/physiol Actions
Dothiepin hydrochloride is a tricyclic antidepressant.
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Santabhanu Chakrabarti et al.
European journal of pediatrics, 169(1), 113-115 (2009-04-07)
This case highlights the importance of considering drug ingestion when the clinical features at presentation are unusual. To our knowledge, this is the first report of atrial flutter secondary to tricyclic antidepressant (TCA) overdose in a child.
Helen Bergen et al.
Journal of affective disorders, 123(1-3), 95-101 (2009-10-30)
Antidepressants are used frequently in non-fatal self-poisoning. There are national guidelines for prescribing antidepressants. There have been few investigations of how non-fatal self-poisoning with antidepressants varies in relation to prescribing and to patient characteristics. A comparative study of the use
[Transitory acute psychosis with serotoninergic syndrome at the time of an intoxication by dosulepin associated with doxylamine and ethanol].
Hafid Belhadj-Tahar et al.
Therapie, 61(6), 540-543 (2007-03-14)
Prescribing of venlafaxine and dosulepin in primary care.
R Hamish McAllister-Williams et al.
Journal of psychopharmacology (Oxford, England), 20(6), 868-868 (2006-10-25)
Jens Drachmann Bukh et al.
Nordic journal of psychiatry, 63(4), 347-351 (2009-04-07)
The relative efficacy of the various classes of antidepressants has not been established. Observational studies in naturalistic settings are important in evaluating treatment outcomes with antidepressants, since controlled clinical trials include only a minority of patients present in clinical practice.
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