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D9570

Sigma-Aldrich

Dothiepin hydrochloride

≥98% (HPLC)

Synonym(s):

3-Dibenzo[b,e]thepin-11(6H)-ylidine-N,N-dimethyl-1-propanamine hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C19H21NS·HCl
CAS Number:
897-15-4
Molecular Weight:
331.90
EC Number:
212-978-8
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

form

solid

solubility

DMSO: ≥26 mg/mL

storage temp.

room temp

InChI

1S/C19H21NS.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;

InChI key

XUPZAARQDNSRJB-CULRIWENSA-N

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Biochem/physiol Actions

Dothiepin hydrochloride is a tricyclic antidepressant.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Peter Lepping et al.
Addiction (Abingdon, England), 102(7), 1166-1167 (2007-06-15)
Tricyclic antidepressants sometimes trigger mania in bipolar patients, but little is known about their potential for abuse in this regard. We describe a man with bipolar disorder and alcohol dependency who abused dosulepin repeatedly in order to induce manic episodes.
H S Kiran et al.
The Journal of the Association of Physicians of India, 58, 120-122 (2010-07-27)
Tricyclic antidepressants (TCAs) may have dangerous cardiac effects in overdose. ECG is useful as both a screening tool for tricyclic antidepressant exposure and as a prognostic indicator. TCA overdose may produce various ECG changes. We report a case of Dothiepin
Case of epirubicin-induced cardiomyopathy in familial cardiomyopathy.
Kate E Shipman et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 29(18), e537-e538 (2011-04-13)
Delirium as a symptom of tricyclic antidepressant withdrawal.
Jacob Alexander et al.
The Australian and New Zealand journal of psychiatry, 44(9), 863-863 (2010-09-08)
C Amey
Journal of affective disorders, 125(1-3), 111-115 (2010-06-24)
Antidepressant-induced switch to mania has not been thoroughly characterized in bipolar disorder and is even less well understood in unipolar depression. I describe, as a first-person narrative, my own experience of psychotic mania, which was suspected to have been induced
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