D9302
Diacerein
≥95% (HPLC)
Synonym(s):
1,8-Diacetoxy-3-carboxyanthraquinone
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About This Item
Product Name
Diacerein, ≥95% (HPLC)
InChI key
TYNLGDBUJLVSMA-UHFFFAOYSA-N
InChI
1S/C19H12O8/c1-8(20)26-13-5-3-4-11-15(13)18(23)16-12(17(11)22)6-10(19(24)25)7-14(16)27-9(2)21/h3-7H,1-2H3,(H,24,25)
SMILES string
CC(=O)Oc1cccc2C(=O)c3cc(cc(OC(C)=O)c3C(=O)c12)C(O)=O
assay
≥95% (HPLC)
form
powder
Quality Level
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Biochem/physiol Actions
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Can Product D9302, Diacerein, be dissolved in DMSO?
Yes. Diacerein is soluble in DMSO at 1 mg/mL. The compound is also soluble in acetic acid at a concentration of 25 mg in 8 mL, as stated on the specification sheet.
What is the biological activity of Product D9302, Diacerein?
Martindale, 30th ed. indicates that "Diacerein is a non-steroidal anti-inflammatory agent that has been used in musculoskeletal and joint disorders." Diacerein acts by inhibiting interleukin-1. The chemicals encyclopedia published by the Royal Society of Chemistry, 11th ed., indicates that Diacerein "demonstrates anti-arthritic activity without inhibiting prostaglandin synthesis".
What is the mechanism of action of Product D9302, Diacerein?
"Diacerein is a slow acting symptomatic treatment of osteoarthritis which has demonstrated efficacy on functional manifestations of osteoarthritis and on the structural component. Two mechanisms of action have been validated: in vitro inhibition of interleukin-1 (IL-1) synthesis, the main cytokine involved in cartilage destruction, and activity on the synthesis of proteoglycans, and hyaluronic acid, the principal component of cartilage. Other studies presented here have provided further details concerning other mechanisms of action of diacerein", according to Presse Med., 33(9 Pt 2), S10-S12 (2004).
What is the melting point of Product D9302, Diacerein?
The chemicals encyclopedia published by the Royal Society of Chemistry (11th ed., entry #2939) reports a melting point of 217-218°C.
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