D8821
Dextran from Leuconostoc mesenteroides
average mol wt 60,000-76,000
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Linear Formula:
(C6H10O5)n
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biological source
bacterial (Leuconostoc mesenteroides)
Quality Level
form
powder
optical activity
[α]20/D 190 to 201 °, c = 2% (w/v) in water
mol wt
average mol wt 60,000-76,000
color
white to off-white
mp
483 °C ((901 °F ))
solubility
water: 100 mg/mL at 25 °C, colorless to faintly yellow
storage temp.
2-8°C
InChI
1S/C18H32O16/c19-1-5(21)9(23)10(24)6(22)3-31-17-16(30)14(28)12(26)8(34-17)4-32-18-15(29)13(27)11(25)7(2-20)33-18/h1,5-18,20-30H,2-4H2
InChI key
FZWBNHMXJMCXLU-UHFFFAOYSA-N
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General description
Dextran is an extracellular bacterial polymer of D-glucopyranose. It consists of α-(1→6) linkage in the main chain with a variable amount of α-(1→2), α-(1→3), α-(1→4) branched linkages. Dextran from L. mesenteroides B512F comprises 95% of α- (1→6) linkages and 5% of α-(1→3) branch linkages. Insoluble dextran from L. mesenteroides 1299 contains 63% α-(1→6), 27% of α-(1→2) and 8% of α-(1→3) linkages.
Application
Dextran from Leuconostoc mesenteroides has been used:
- in resuspension of pellets and in Hanks′ balanced salt solution (HBSS) for the isolation of vascular nuclei from frozen post-mortem brain tissue
- to prepare dextran solution in phosphate buffer saline and to maintain corneal hydration and restore corneal thickness to physiological levels of human eyes
- as a polymer solution in the in situ aqueous two-phase systems (ATPS) formation with lysozyme PEGylation reaction
Use of dextrans as long and hydrophilic spacer arms improves the performance of immobilized proteins acting on macromolecules.
Biochem/physiol Actions
Dextran is commercially available as a drug, especially as a blood plasma volume expander. This bacterial polysaccharide has several applications, such as adjuvant, emulsifier, carrier, and stabilizer in the food, pharmaceutical, and chemical industries. Dextran is used in the thickening of jam and ice cream in the food industry. It prevents sugar crystallization and retains moisture. This helps in preserving the flavor and appearance of several food items.
Other Notes
To gain a comprehensive understanding of our extensive range of Dextrans for your research, we encourage you to visit our Carbohydrates Category page.
WGK
WGK 2
Certificates of Analysis (COA)
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Janice M Dias et al.
Experimental eye research, 115, 41-46 (2013-06-27)
Corneal biomechanics is an essential parameter for developing diagnostic and treatment methods of corneal-related diseases. It is widely accepted that corneal mechanical strength stems from the stroma's collagenous composition. However, more comprehensive insight into the mechanical properties within the stroma
Farwa Sarwat et al.
International journal of biological sciences, 4(6), 379-386 (2008-10-28)
On the basis of high enzyme activity a newly isolated strain of L. mesenteroides CMG713 was selected for dextran production. For maximum yield of dextran, effects of various parameters such as pH, temperature, sucrose concentration and incubation period were studied.
Elizabeth M Bradshaw et al.
Nature neuroscience, 16(7), 848-850 (2013-05-28)
In our functional dissection of the CD33 Alzheimer's disease susceptibility locus, we found that the rs3865444(C) risk allele was associated with greater cell surface expression of CD33 in the monocytes (t50 = 10.06, P(joint) = 1.3 × 10(-13)) of young
Boon M Teo et al.
Biochimica et biophysica acta, 1830(10), 4838-4847 (2013-07-03)
Liposomes have gained immerse attention in the field of drug delivery as carriers of therapeutic molecules. Their modification with a polymer either to make them stealth (e.g. using PEG) and/or more stable (e.g. using poly(dopamine) (PDA)) is a crucial aspect
Marisa A Gallicchio et al.
Biochimica et biophysica acta, 1833(12), 2922-2932 (2013-06-12)
Chronic hyperglycaemia during diabetes leads to non-enzymatic glycation of proteins to form advanced glycation end products (AGEs) that contribute to nephropathy. We describe AGE uptake in LLC-PK1 and HK2 proximal tubule cell lines by macropinocytosis, a non-specific, endocytic mechanism. AGE-BSA
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