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Merck
CN

D8399

Danazol

≥98%

Synonym(s):

17β-Hydroxy-2,4,17α-pregnadien-20-yno[2,3-d]isoxazole, 2,4,17α-Pregnadien-20-yno[2,3-d]­isoxa­zol-17-ol

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About This Item

Empirical Formula (Hill Notation):
C22H27NO2
CAS Number:
17230-88-5
Molecular Weight:
337.46
NACRES:
NA.77
PubChem Substance ID:
24277708
UNSPSC Code:
51111800
EC Number:
241-270-1
MDL number:
MFCD00056838
Assay:
≥98%
Form:
powder
Quality level:
200

Key Documents

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InChI key

POZRVZJJTULAOH-ZIKCMSSPSA-N

InChI

1S/C22H27NO2/c1-4-22(24)10-8-18-16-6-5-15-11-19-14(13-23-25-19)12-20(15,2)17(16)7-9-21(18,22)3/h1,11,13,16-18,24H,5-10,12H2,2-3H3/t16?,17?,18?,20?,21?,22-/m0/s1

SMILES string

CC12Cc3cnoc3C=C1CCC4C2CCC5(C)C4CC[C@@]5(O)C#C

assay

≥98%

form

powder

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

Quality Level

200

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Related Categories

Biochem/physiol Actions

Danazol is a weak androgen; anterior pituitary suppressant.

Features and Benefits

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

兴奋剂蛋白同化制剂
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Certificates of Analysis (COA)

Lot/Batch Number
BCCN6582
BCCM9049
BCCJ9969
BCCH0214
BCCG4030

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Timothy J Craig
Allergy and asthma proceedings, 29(3), 225-231 (2008-04-05)
Hereditary angioedema (HAE) is an autosomal dominant disease characterized by painful, recurrent attacks of inflammation affecting the hands, feet, face, abdomen, urogenital tract, and the larynx. The inflammation can be disfiguring, debilitating, quite painful, and, in the case of laryngeal
Pagalavan Letchumanan et al.
Seminars in arthritis and rheumatism, 40(4), 298-306 (2010-06-15)
To review and summarize published information on the use, effectiveness, and adverse effects of danazol in patients with systemic lupus erythematosus (SLE). A MEDLINE search from January 1950 to July 2009 was conducted using 2 search strategies retrieving 51 and
H Farkas et al.
Allergy, 67(12), 1586-1593 (2012-10-03)
Hereditary angioedema is a potentially life-threatening disorder, because edema occurring in the mucosa of the upper airways can lead to suffocation. The management of HAE consists of avoiding the triggering factors, prophylaxis, and the acute treatment of edematous episodes. Medical
E Miller
Seminars in veterinary medicine and surgery (small animal), 12(3), 167-169 (1997-08-01)
Currently available therapeutic protocols for immune-mediated diseases in dogs and cats can be associated with poor response rates and a high incidence of side effects. The development of multidrug protocols often results in a synergistic effect that more efficiently suppresses
H Beaumont et al.
The Cochrane database of systematic reviews, (3)(3), CD001017-CD001017 (2007-07-20)
Heavy menstrual bleeding (HMB) is an important cause of ill health in pre menopausal women. Medical therapy, with the avoidance of possibly unnecessary surgery is an attractive treatment option, but there is considerable variation in practice and uncertainty about the
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