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Merck
CN

D7409

2′,3′-Dideoxyguanosine 5′-triphosphate sodium salt

≥90% (HPLC)

Synonym(s):

ddGTP

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About This Item

Empirical Formula (Hill Notation):
C10H16N5O12P3
CAS Number:
68726-28-3
Molecular Weight:
491.18
NACRES:
NA.51
PubChem Substance ID:
24894133
UNSPSC Code:
41106305
MDL number:
MFCD00079152
Assay:
≥90% (HPLC)
Form:
powder
Solubility:
water: 5 mg/mL, clear, colorless
Storage temp.:
−20°C

Key Documents

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InChI

1S/C10H16N5O12P3.Na/c11-10-13-8-7(9(16)14-10)12-4-15(8)6-2-1-5(25-6)3-24-29(20,21)27-30(22,23)26-28(17,18)19;/h4-6H,1-3H2,(H,20,21)(H,22,23)(H2,17,18,19)(H3,11,13,14,16);/q;+1/p-1/t5-,6+;/m0./s1

SMILES string

[Na+].OP([O-])(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]1CC[C@@H](O1)n2cnc3C(=O)NC(=N)Nc23

InChI key

XCOBCPBPAINELA-RIHPBJNCSA-M

assay

≥90% (HPLC)

form

powder

solubility

water: 5 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

100

Gene Information

human ... HRAS(3265)

Related Categories

Application

2′,3′-Dideoxyguanosine 5′-triphosphate (ddGTP) is use as a chain terminator inhibitor and a inhibitor of telomerase(s).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
069K1324V
069K1324
073K1407
035K0884
033H0940

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Nathan A Tanner et al.
Nucleic acids research, 37(4), e27-e27 (2009-01-22)
We present a simple technique for visualizing replication of individual DNA molecules in real time. By attaching a rolling-circle substrate to a TIRF microscope-mounted flow chamber, we are able to monitor the progression of single-DNA synthesis events and accurately measure
H Zhang et al.
Antiviral research, 24(1), 43-57 (1994-05-01)
Two mutants of HIV-1 reverse transcriptase (RT), Tyr-188-->His and Glu-138-->Arg have been prepared and their catalytic properties and sensitivities to inhibitors studied. As compared to wild type RT, a reduction in catalytic efficiency and turn over number was observed, especially
H Pelemans et al.
Molecular pharmacology, 57(5), 954-960 (2000-04-25)
Trp-229 is part of the non-nucleoside reverse transcriptase inhibitor (NNRTI)-binding pocket of HIV type 1 (HIV-1) reverse transcriptase (RT), and is also part of the "primer grip" of HIV-1 RT. Using site-directed mutagenesis, seven RT mutants were constructed bearing the
Tadamasa Sasaki et al.
The Plant journal : for cell and molecular biology, 47(5), 802-810 (2006-07-22)
RNA editing is found in various transcripts from land plant chloroplasts. In tobacco chloroplasts, C-to-U conversion occurs at 36 specific sites including two sites identified in this work. Our RNA editing assay system using chloroplast extracts facilitated biochemical analyses of
H Jonckheere et al.
The Journal of biological chemistry, 269(41), 25255-25258 (1994-10-14)
Determination of the three-dimensional structure of the human immunodeficiency virus type-1 (HIV-1) reverse transcriptase (RT) has indicated a totally different folding for the 51-kDa subunit (p51) than for the 66-kDa subunit (p66). The polymerase catalytic site is located on the
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