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Merck
CN

D7017

Dynorphin A Porcine Fragment 1-13

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C75H126N24O15
CAS Number:
72957-38-1
Molecular Weight:
1603.95
NACRES:
NA.32
PubChem Substance ID:
24894071
UNSPSC Code:
12352202
MDL number:
MFCD00076366

Key Documents

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Product Name

Dynorphin A Porcine Fragment 1-13, ≥97% (HPLC)

form

powder

InChI

1S/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)

SMILES string

CCC(C)C(NC(=O)C(CCCNC(N)=N)NC(=O)C(CCCNC(N)=N)NC(=O)C(CC(C)C)NC(=O)C(Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)C(N)Cc2ccc(O)cc2)C(=O)NC(CCCNC(N)=N)C(=O)N3CCCC3C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(O)=O

InChI key

OVVIBUHLQIYUEU-UHFFFAOYSA-N

assay

≥97% (HPLC)

composition

Peptide content, ≥50%

UniProt accession no.

P01214

storage temp.

−20°C

Quality Level

200

Gene Information

pig ... PDYN(445529)

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Application

Dynorphin A Porcine Fragment 1-13 has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

Biochem/physiol Actions

Dynorphin (Dyn) (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca2+]i level and contributes to the loss of neurons affecting neuronal viability.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
SLCN5933
SLCJ5025
SLBV4020
SLBN9253V
SLBK8305V

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Xin Sun et al.
Life sciences, 78(21), 2516-2522 (2005-12-13)
To investigate the relaxation effect and underlying mechanism of U50,488H (a selective kappa-opioid receptor agonist) in pulmonary artery in the rat. Isolated pulmonary artery ring was perfused and the tension of the vessel was measured. U50,488H relaxed the pulmonary artery
K F Hauser et al.
Experimental neurology, 160(2), 361-375 (2000-01-05)
Dynorphin A is an endogenous opioid peptide that preferentially activates kappa-opioid receptors and is antinociceptive at physiological concentrations. Levels of dynorphin A and a major metabolite, dynorphin A (1-13), increase significantly following spinal cord trauma and reportedly contribute to neurodegeneration
Jia-Xu Chen et al.
Cellular and molecular neurobiology, 27(1), 1-10 (2006-07-22)
This study was designed to investigate the effect of acute and chronic high-intensity treadmill exercise on changes in plasma lactate and brain neuropeptide (NPY), leucine-enkephalin (L-ENK), and dynorphin A(1-13) (DYN A(1-13)). Avidin-biotin complex (ABC) immunohistochemistry and image pattern analysis were
Jing Liang et al.
Neuropharmacology, 58(1), 233-240 (2009-07-15)
Our previous studies have demonstrated that morphine-induced conditioned place preference (CPP) can be inhibited by 2 Hz electroacupuncture (EA). This inhibition can be blocked by either the opioid receptor antagonist naloxone (i.p.) or lesion in the nucleus accumbens (NAc), providing
M Hiramatsu et al.
Methods and findings in experimental and clinical pharmacology, 20(7), 595-599 (1998-11-20)
The role of kappa-opioid receptor agonists on learning and memory is controversial. In this review, the effects of dynorphin A (1-13) and U-50,488H on learning and memory impairments in mice and rats are summarized. Muscarinic cholinergic antagonists and a nicotinic
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