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Merck
CN

D6790

Defensin HNP-2 human

≥95% (HPLC)

Synonym(s):

Neutrophil Peptide-2

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About This Item

Empirical Formula (Hill Notation):
C147H217N43O37S6
CAS Number:
99287-07-7
Molecular Weight:
3370.95
NACRES:
NA.32
PubChem Substance ID:
329798836
UNSPSC Code:
12352202
MDL number:
MFCD00076222

Key Documents

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Product Name

Defensin HNP-2 human, ≥95% (HPLC)

InChI

1S/C147H217N43O37S6/c1-13-73(6)114-139(222)168-76(9)118(201)163-63-110(196)170-96(48-50-113(199)200)127(210)172-92(31-22-52-159-145(152)153)125(208)171-93(32-23-53-160-146(154)155)126(209)178-98(58-81-35-41-85(192)42-36-81)123(206)165-65-112(198)186-117(79(12)191)141(224)184-106-70-232-229-67-103-134(217)173-94(33-24-54-161-147(156)157)128(211)189-116(75(8)15-3)142(225)190-55-25-34-108(190)138(221)167-78(11)120(203)181-105(136(219)187-114)69-231-230-68-104(135(218)185-107(143(226)227)71-233-228-66-89(148)121(204)176-100(133(216)182-103)59-82-37-43-86(193)44-38-82)183-132(215)99(57-80-26-17-16-18-27-80)175-119(202)77(10)166-129(212)102(61-84-62-162-90-29-20-19-28-88(84)90)179-130(213)97(56-72(4)5)177-124(207)91(30-21-51-158-144(150)151)169-111(197)64-164-122(205)95(47-49-109(149)195)174-131(214)101(60-83-39-45-87(194)46-40-83)180-140(223)115(74(7)14-2)188-137(106)220/h16-20,26-29,35-46,62,72-79,89,91-108,114-117,162,191-194H,13-15,21-25,30-34,47-61,63-71,148H2,1-12H3,(H2,149,195)(H,163,201)(H,164,205)(H,165,206)(H,166,212)(H,167,221)(H,168,222)(H,169,197)(H,170,196)(H,171,208)(H,172,210)(H,173,217)(H,174,214)(H,175,202)(H,176,204)(H,177,207)(H,178,209)(H,179,213)(H,180,223)(H,181,203)(H,182,216)(H,183,215)(H,184,224)(H,185,218)(H,186,198)(H,187,219)(H,188,220)(H,189,211)(H,199,200)(H,226,227)(H4,150,151,158)(H4,152,153,159)(H4,154,155,160)(H4,156,157,161)/t73-,74-,75-,76-,77-,78-,79+,89-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,114-,115-,116-,117-/m0/s1

SMILES string

CC[C@H](C)[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](C)NC(=O)[C@H](Cc5c[nH]c6ccccc56)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc7ccc(O)cc7)NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc8ccc(O)cc8)NC(=O)[C@@H](N)CSSC[C@H](NC3=O)C(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)[N@@H]9CCC[C@H]9C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc%10ccc(O)cc%10)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](C)NC1=O)[C@@H](C)O)[C@@H](C)CC

InChI key

GRZXCHIIZXMEPJ-HTLKCAKFSA-N

assay

≥95% (HPLC)

form

solid

UniProt accession no.

P59665

antibiotic activity spectrum

fungi
mycobacteria
viruses

mode of action

cell membrane | interferes

storage temp.

−20°C

Quality Level

200

Gene Information

human ... DEFA1(1667)

Biochem/physiol Actions

This is an endogenous antibiotic peptide and monocyte chemotactic peptide produced by human neutrophils. Defensins are a family of 3-4 kDa (29-34 amino acids) peptides found in the granules of mammalian phagocytes. The members of this famuly are variably arginine-rich and all share 6 conserved cysteine residues that participate in intramolecular disulfide bonds.

General description

Chemical structure: peptide

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051M8741
019K8737
108K1657
098K8726
088K1221

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Human β-defensin-2.
Schroder J.M., and Harder, J.
The International Journal of Biochemistry & Cell Biology, 31, 645-651 (1998)
S H White et al.
Current opinion in structural biology, 5(4), 521-527 (1995-08-01)
Defensins comprise a structural class of small cationic peptides that exert broad-spectrum antimicrobial activities through membrane permeabilization. Their predominantly beta-sheet structure, stabilized by three disulfide bonds, distinguishes them from other antimicrobial peptides which typically form amphiphilic helices. Defensins bind to
β-Defensins: endogenous antibiotics of the innate host defense response.
Diamond G., and Bevins, C.L.
Clinical Immunology and Immunopathology, 88, 221-225 (1995)
M E Selsted et al.
Infection and immunity, 55(9), 2281-2286 (1987-09-01)
A broad-spectrum antimicrobial peptide present in guinea pig neutrophils was isolated, characterized biochemically, and assessed for microbicidal range and potency in vitro. The guinea pig neutrophil peptide (GPNP) was purified to homogeneity from a granule-rich subcellular fraction of peritoneal exudate

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