D6500
2′-Deoxyadenosine 5′-triphosphate disodium salt
≥97%
Synonym(s):
dATP-Na2
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About This Item
Empirical Formula (Hill Notation):
C10H14N5Na2O12P3
CAS Number:
Molecular Weight:
535.15
PubChem Substance ID:
eCl@ss:
32160414
UNSPSC Code:
41106305
NACRES:
NA.51
EC Number:
277-809-2
MDL number:
Assay:
≥97%
Biological source:
natural (inorganic)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
Storage temp.:
−20°C
biological source
natural (inorganic)
Quality Level
assay
≥97%
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
[Na+].[Na+].Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O3
InChI
1S/C10H16N5O12P3.2Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;/q;2*+1/p-2/t5-,6+,7?;;/m0../s1
InChI key
JEKDCIBJADJZSK-LNUHRGGJSA-L
Application
2′-Deoxyadenosine 5′-triphosphate disodium salt has been used:
- for Smac- X-linked inhibitor of apoptosis protein (Smac-XIAP) binding assay.
- as a component of polymerase chain reaction (PCR) using AM-toxin primers.
- to determine the affinity constant (Kd) with the transcription termination factor Rho.
- to determine the activity of poly ADP-ribose polymerase 1 (PAPR-1 ).
2′-Deoxyadenosine 5′-triphosphate (dATP) is used as a substrate by a variety of polymerases including DNA polymerase(s) and reverse transcriptase(s).
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA
Gemble S, et al.
PLoS Genetics, 11(7), e1005384-e1005384 (2015)
Jennifer N Patro et al.
Biochemistry, 48(1), 180-189 (2008-12-17)
We used a series of dNTP analogues in conjunction with templates containing modified bases to elucidate the role that N(2) of a purine plays during dNTP polymerization by human DNA polymerase alpha. Removing N(2) from dGTP had small effects during
Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64
Cheng J, et al.
American Journal of Human Genetics, 89(1), 56-66 (2011)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D6500-10MG | 04061833006948 |
| D6500-100MG | 04061833006931 |
| D6500-25MG | 04061833006955 |