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Merck
CN

D6500

2′-Deoxyadenosine 5′-triphosphate disodium salt

≥97%

Synonym(s):

dATP-Na2

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About This Item

Empirical Formula (Hill Notation):
C10H14N5Na2O12P3
CAS Number:
74299-50-6
Molecular Weight:
535.15
PubChem Substance ID:
24894029
eCl@ss:
32160414
UNSPSC Code:
41106305
NACRES:
NA.51
EC Number:
277-809-2
MDL number:
MFCD00080335

Key Documents

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Product Name

2′-Deoxyadenosine 5′-triphosphate disodium salt, ≥97%

InChI key

JEKDCIBJADJZSK-LNUHRGGJSA-L

InChI

1S/C10H16N5O12P3.2Na/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19;;/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19);;/q;2*+1/p-2/t5-,6+,7?;;/m0../s1

SMILES string

[Na+].[Na+].Nc1ncnc2n(cnc12)C3C[C@H](O)[C@@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)O3

biological source

natural (inorganic)

assay

≥97%

form

powder

solubility

water: 50 mg/mL, clear, colorless

storage temp.

−20°C

Quality Level

200

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Application

2′-Deoxyadenosine 5′-triphosphate (dATP) is used as a substrate by a variety of polymerases including DNA polymerase(s) and reverse transcriptase(s).
2′-Deoxyadenosine 5′-triphosphate disodium salt has been used:
  • for Smac- X-linked inhibitor of apoptosis protein (Smac-XIAP) binding assay.
  • as a component of polymerase chain reaction (PCR) using AM-toxin primers.
  • to determine the affinity constant (Kd) with the transcription termination factor Rho.
  • to determine the activity of poly ADP-ribose polymerase 1 (PAPR-1 ).

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000513811
0000513811
0000512512
0000512512
0000451075

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Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64
Cheng J, et al.
American Journal of Human Genetics, 89(1), 56-66 (2011)
Catalytic Cooperativity among Subunits of Escherichia coli Transcription Termination Factor Rho KINETICS AND SUBSTRATE STRUCTURAL REQUIREMENTS
Browne R J, et al.
The Journal of Biological Chemistry, 280(14), 13292-13299 (2005)
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA
Gemble S, et al.
PLoS Genetics, 11(7), e1005384-e1005384 (2015)
Jennifer N Patro et al.
Biochemistry, 48(1), 180-189 (2008-12-17)
We used a series of dNTP analogues in conjunction with templates containing modified bases to elucidate the role that N(2) of a purine plays during dNTP polymerization by human DNA polymerase alpha. Removing N(2) from dGTP had small effects during
Michael Trostler et al.
Biochemistry, 48(21), 4633-4641 (2009-04-08)
We used a series of dATP and dGTP analogues to determine how DNA polymerase I from Bacillus stearothermophilus (BF), a prototypical A family polymerase, uses N-1, N(2), N-3, and N(6) of purine dNTPs to differentiate between right and wrong nucleotide
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