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Merck
CN

D6277

N-Decanoyl-N-methylglucamine

≥98% (GC)

Synonym(s):

N-(D-Glucityl)-N-methyldecanamide, N-Decanoyl-N-methyl-D-glucamine, MEGA-10

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About This Item

Empirical Formula (Hill Notation):
C17H35NO6
CAS Number:
85261-20-7
Molecular Weight:
349.46
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
24894017
MDL number:
MFCD00036801
Beilstein/REAXYS Number:
6974359

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InChI

1S/C17H35NO6/c1-3-4-5-6-7-8-9-10-15(22)18(2)11-13(20)16(23)17(24)14(21)12-19/h13-14,16-17,19-21,23-24H,3-12H2,1-2H3

SMILES string

OCC(O)C(O)C(O)C(O)CN(C)C(CCCCCCCCC)=O

InChI key

UMWKZHPREXJQGR-UHFFFAOYSA-N

description

non-ionic

assay

≥98% (GC)

form

powder

mol wt

349.46 g/mol

technique(s)

ligand binding assay: suitable, protein purification: suitable

CMC

6-7 mM (20-25°C)

storage temp.

2-8°C

Quality Level

200

Related Categories

General description

N-Decanoyl-N-methylglucamine is a nonionic detergent used in lysis buffers.

Application

N-Decanoyl-N-methylglucamine has been used in a study to assess the effect of surfactants on wetting behavior of super-hydrophobic surfaces. It has also been used in a study to investigate the clinical impact of Human metapneumovirus (hMPV) vaccines on Syrian golden hamsters.
Non-ionic, dialyzable detergent used for the solubilization of membrane proteins

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000491487
0000491483
0000491487
0000491483
0000429949

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R Mohammadi et al.
Langmuir : the ACS journal of surfaces and colloids, 20(22), 9657-9662 (2004-10-20)
The effect of surfactants on wetting behavior of super-hydrophobic surfaces was investigated. Super-hydrophobic surfaces were prepared of alkylketene dimer (AKD) by casting the AKD melt in a specially designed mold. Time-dependent studies were carried out, using the axisymmetric drop shape
Khemraj Budachetri et al.
mBio, 11(4) (2020-07-30)
Ehrlichia chaffeensis is an obligatory intracellular bacterium that causes human monocytic ehrlichiosis, an emerging disease transmitted by the Lone Star tick, Amblyomma americanum. E. chaffeensis outer membrane protein entry triggering protein of Ehrlichia (EtpE) is necessary for bacterial entry into
Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins
Chuang, J., et al.
Analytical Biochemistry, 418, 3-3 (2011)
Shohei Nakamura et al.
Langmuir : the ACS journal of surfaces and colloids, 24(1), 15-18 (2007-12-07)
Solubilization of benzene, toluene, ethylbenzene, n-propylbenzene, n-butylbenzene, n-pentylbenzene, and n-hexylbenzene into micelles of decanoyl-N-methylglucamide (Mega-10) was studied, where equilibrium concentrations of the above solubilizates were determined spectrophotometrically at 303.2 K. The concentration of the above solubilizates remained constant below the
R C Poole et al.
The Biochemical journal, 283 ( Pt 3), 855-862 (1992-05-01)
1. Intact erythrocytes were incubated with 100 microM-4,4'-di-isothiocyanostilbene-2,2'-disulphonate (DIDS), a concentration sufficient to inhibit lactate transport irreversibly by 65%. DIDS-labelled proteins were detected by immunoblotting of erythrocyte membrane proteins with an anti-DIDS antibody. Labelled polypeptides of 35-45 kDa in rat
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