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Key Documents

D5943

Sigma-Aldrich

2-(3,4-Dimethoxy-benzoylamino)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid amide

≥98% (HPLC), solid

Synonym(s):

Flt-3 inhibitor

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5 MG
CN¥1,946.32
25 MG
CN¥8,865.45

About This Item

Empirical Formula (Hill Notation):
C18H20N2O4S
CAS Number:
Molecular Weight:
360.43
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77

CN¥1,946.32


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New, lower price on this item!

Quality Level

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light
under inert gas

color

white to off-white

solubility

H2O: <2 mg/mL
DMSO: ~8 mg/mL

storage temp.

−20°C

SMILES string

COc1ccc(cc1OC)C(=O)Nc2sc3CCCCc3c2C(N)=O

InChI

1S/C18H20N2O4S/c1-23-12-8-7-10(9-13(12)24-2)17(22)20-18-15(16(19)21)11-5-3-4-6-14(11)25-18/h7-9H,3-6H2,1-2H3,(H2,19,21)(H,20,22)

InChI key

FSPQCTGGIANIJZ-UHFFFAOYSA-N

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Show Differences

1 of 4

This Item
C1368A6355B6060
BVT.948 &#8805;98% (HPLC), solid

B6060

BVT.948

form

solid

form

solid

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

H2O: <2 mg/mL, DMSO: ~8 mg/mL

solubility

H2O: <2 mg/mL, DMSO: >7 mg/mL

solubility

DMSO: ≥4 mg/mL

solubility

DMSO: 18 mg/mL, H2O: insoluble

storage condition

protect from light, under inert gas

storage condition

-

storage condition

desiccated, under inert gas

storage condition

desiccated, protect from light, under inert gas

Biochem/physiol Actions

Flt-3 (fms-related tyrosine kinase 3) inhibitor

Features and Benefits

This compound is featured on the PDGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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    Raymond J Patch et al.
    Bioorganic & medicinal chemistry letters, 16(12), 3282-3286 (2006-04-04)
    A series of 2-acylaminothiophene-3-carboxamides has been identified which exhibit potent inhibitory activity against the FLT3 tyrosine kinase. Compound 44 inhibits the isolated enzyme (IC50 = 0.027 microM) and blocks the proliferation of MV4-11 cells (IC50 = 0.41 microM). Structure-activity relationship

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