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D5670

Sigma-Aldrich

Sodium deoxycholate monohydrate

BioXtra, ≥99.0% (titration)

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Synonym(s):
3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt
Empirical Formula (Hill Notation):
C24H39NaO4 · H2O
CAS Number:
145224-92-6
Molecular Weight:
432.57
Beilstein:
3643164
EC Number:
206-132-7
MDL number:
MFCD00150750
UNSPSC Code:
12161900
PubChem Substance ID:
24893956
NACRES:
NA.25

description

anionic

Quality Level

200

product line

BioXtra

Assay

≥99.0% (titration)

form

powder

optical activity

[α]20/D +44±2° in H2O(lit.)

mol wt

432.57 g/mol

technique(s)

electrophoresis: suitable
immunoprecipitation (IP): suitable

impurities

Insoluble matter, passes filter test
≤0.5% Cholic acid

pH

7.5-9.5 (20 °C, 0.1 M in H2O)

solubility

H2O: 0.1 M, clear, colorless

anion traces

sulfate (SO42-): ≤0.02%

cation traces

Al: ≤0.002%
Ba: ≤0.0005%
Bi: ≤0.0005%
Ca: ≤0.05%
Cd: ≤0.0005%
Co: ≤0.0005%
Cr: ≤0.0005%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.010%
Li: ≤0.0005%
Mg: ≤0.002%
Mn: ≤0.0005%
Mo: ≤0.0005%
Ni: ≤0.0005%
Pb: ≤0.0005%
Sr: ≤0.002%
Zn: ≤0.0005%

absorption

≤0.08 at 280 in H2O at 0.1 M
≤0.10 at 260 in H2O at 0.1 M

SMILES string

O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3CCC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C

InChI

1S/C24H40O4.Na.H2O/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);;1H2/q;+1;/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;;/m1../s1

InChI key

NDVHNZISGVSFMP-WTCAICSISA-M

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Related Categories

General description

Sodium deoxycholate (SDC) monohydrate is a bile acid salt.

Application

Sodium deoxycholate monohydrate has been used in a study to assess a method for the immobilization of lipoxygenase in an alginate-silicate gel matrix. It has also been used in a study to investigate the in vitro dissolution of gall stones.
Powerful solubilization agent; used in the solubilization of estrogen synthetase from human placental microsomes.

Biochem/physiol Actions

Bile Salt

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Effect of various lipid-bile salt mixed micelles on the intestinal absorption of amphotericin-B in rat
Dangi, J., et al.
Drug Devel. Ind. Pharm., 24, 631-631 (1998)
Liquid crystals and phase equilibria binary bile salt-water systems.
Marques EF, et al.
Langmuir, 16(11), 5178-5186 (2000)
Immobilization of lipoxygenase in an alginate-silicate solgel matrix: formation of fatty acid hydroperoxides
Hsu, A., et al.
Biotechnology Letters, 19, 71-71 (1997)
R P Modi et al.
Journal of the Indian Medical Association, 89(5), 129-132 (1991-05-01)
An in vitro study on dissolution of 36 gall-stones obtained from 3 patients (12 stones from each patient) was carried out in heparin, bile salt and clofibrate solutions of different strengths. Heparin was found to be a poor solvent while
Suguru Yamasaki et al.
Scientific reports, 9(1), 177-177 (2019-01-19)
During infection, Salmonella senses and responds to harsh environments within the host. Persistence in a bile-rich environment is important for Salmonella to infect the small intestine or gallbladder and the multidrug efflux system AcrAB-TolC is required for bile resistance. The
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