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Merck
CN

D5520

Dimethyl dicarbonate

for histidine methylation

Synonym(s):

DMPC, Dimethyl pyrocarbonate, Pyrocarbonic acid dimethyl ester

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About This Item

Linear Formula:
(CH3OCO)2O
CAS Number:
4525-33-1
Molecular Weight:
134.09
EC Number:
224-859-8
UNSPSC Code:
12352202
PubChem Substance ID:
24893938
Beilstein/REAXYS Number:
956715
MDL number:
MFCD00008419

Key Documents

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InChI key

GZDFHIJNHHMENY-UHFFFAOYSA-N

InChI

1S/C4H6O5/c1-7-3(5)9-4(6)8-2/h1-2H3

SMILES string

COC(=O)OC(=O)OC

biological source

synthetic

form

liquid

refractive index

n20/D 1.392 (lit.)

bp

45-46 °C/5 mmHg (lit.)

density

1.25 g/mL at 25 °C (lit.)

storage temp.

room temp

Application

Methylates one or two histidine residues at the active site of PEP carboxykinase; the resulting inhibition is only partially reversible.

pictograms

Skull and crossbonesCorrosion
GHS06,GHS05

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

185.0 °F

flash_point_c

85 °C

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCBP3724V
BCBM3886V
BCBN4448V
BCBG3522V
BCBF7028V

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