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Merck
CN

D4025

Dimetridazole

Synonym(s):

1,2-Dimethyl-5-nitroimidazole

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About This Item

Empirical Formula (Hill Notation):
C5H7N3O2
CAS Number:
551-92-8
Molecular Weight:
141.13
UNSPSC Code:
51102829
NACRES:
NA.85
PubChem Substance ID:
24893809
EC Number:
209-001-2
Beilstein/REAXYS Number:
130665
MDL number:
MFCD00047046

Key Documents

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InChI key

IBXPYPUJPLLOIN-UHFFFAOYSA-N

InChI

1S/C5H7N3O2/c1-4-6-3-5(7(4)2)8(9)10/h3H,1-2H3

SMILES string

Cc1ncc(n1C)[N+]([O-])=O

form

powder

color

almost white to brownish-yellow

solubility

ethanol: sparingly soluble 96%, H2O: slightly soluble, chloroform: freely soluble, ether: slightly soluble

antibiotic activity spectrum

Gram-negative bacteria, parasites

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

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Application

It is a potential antimicrobial agent against Campylobacter spp. from pigs. It has been used to study antitrichomonad action on Tritrichomonas foetus. Dimetridazole is used to study mechanisms of anti-protozoan nitroimidazole drugs.

pictograms

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GHS07

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Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000145939
0000145939
0000102781
128M4833V
058M4788V

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C J Gebhart et al.
Antimicrobial agents and chemotherapy, 27(1), 55-59 (1985-01-01)
The in vitro activities of 47 antimicrobial agents against 30 isolates of Campylobacter species from pigs were determined by the agar dilution technique. The isolates were obtained from pigs with proliferative enteritis and included 10 strains each of Campylobacter coli
D G Lindmark et al.
Antimicrobial agents and chemotherapy, 10(3), 476-482 (1976-09-01)
Twelve 4- and 5-nitroimidazole derivatives, including metronidazole and two of its metabolites, tinidazole, dimetridazole, and nimorazole, were tested for antitrichomonad action on Tritrichomonas foetus (KV(1)) and Trichomonas vaginalis (ATCC 30001) for mutagenicity on a nitroreductase-positive (TA 100) and a nitroreductase-deficient
M P Callait et al.
Poultry science, 81(8), 1122-1127 (2002-09-05)
Histomoniasis or blackhead is a life-threatening disease of turkeys that is caused by a flagellated protozoan, Histomonas meleagridis. The development of an assay to measure the sensitivity of drugs traditionally used against this parasite, as reputed to be effective against
Harold M J F van der Heijden et al.
Avian pathology : journal of the W.V.P.A, 37(1), 45-50 (2008-01-19)
Histomoniasis is a serious disease in poultry. All chemotherapeutics with known efficacy against its causative agent, Histomonas meleagridis, have been banned from use as prophylactic or therapeutic use in production animals. In a search for possible alternatives, the in vivo
K S Warren et al.
Australian veterinary journal, 81(12), 739-741 (2004-04-15)
Cryptosporidiosis is an enteric disease of animals and humans that can be fatal in immunocompromised individuals. There is no known effective treatment for cryptosporidiosis. Bilbies are threatened marsupials and are bred in captivity as part of a recovery program to
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