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Safety Information

D3179

Sigma-Aldrich

2-Deoxy-D-glucose

≥98% (GC), BioXtra

Synonym(s):

2-Deoxy-D-arabinohexose

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250 MG
CN¥613.19

CN¥613.19

Estimated to ship onJuly 09, 2025Details

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250 MG
CN¥613.19

About This Item

Empirical Formula (Hill Notation):
C6H12O5
CAS Number:
154-17-6
Molecular Weight:
164.16
Beilstein:
1723331
EC Number:
205-823-0
MDL number:
MFCD00151328
UNSPSC Code:
12352201
PubChem Substance ID:
24893732
NACRES:
NA.25

CN¥613.19

Estimated to ship onJuly 09, 2025Details

Request a Bulk Order

biological source

synthetic (organic)

product line

BioXtra

Assay

≥98% (GC)

form

powder

technique(s)

gas chromatography (GC): suitable

impurities

≤0.001% Phosphorus (P)
<0.1% Insoluble matter

ign. residue

<0.1%

color

white

mp

146-147 °C (lit.)

solubility

H2O: 1 M at 20 °C, clear, colorless

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This Item
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2-Deoxy-D-glucose &#8805;98% (GC), BioXtra

D3179

2-Deoxy-D-glucose

2-Deoxy-D-glucose &#8805;98% (GC), crystalline

D8375

2-Deoxy-D-glucose

2-Deoxy-D-glucose &#8805;99% (GC), crystalline

D6134

2-Deoxy-D-glucose

Methyl &#945;-D-glucopyranoside &#8805;99% (GC)

M9376

Methyl α-D-glucopyranoside

biological source

synthetic (organic)

biological source

synthetic

biological source

synthetic (organic)

biological source

synthetic (organic)

assay

≥98% (GC)

assay

≥98% (GC)

assay

≥99% (GC)

assay

≥99% (GC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

H2O: 1 M at 20 °C, clear, colorless

solubility

H2O: 0.250 g/5mL

solubility

H2O: soluble 330 mg/mL, clear, colorless

solubility

water: 50 mg/mL, clear, colorless

form

powder

form

crystalline

form

crystalline

form

powder

Application

2-Deoxy-D-glucose was used in the development of anti-cancer strategies that involve radio- and chemosensitization and oxidative stress.[1][2] It was used in glucoprivic feeding research to invoke and study the processes of counter-regulatory response (CRR).[3]

Biochem/physiol Actions

2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its action on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increases ROS production, and activate AMPK.[2]
2-Deoxy-D-Glucose (2-Deoxyglucose) is a glucose analog that inhibits glycolysis via its actions on hexokinase, the rate limiting step of glycolysis. It is phosphorylated by hexokinase to 2-DG-P which can not be further metabolized by phosphoglucose isomerase. This leads to the accumulation of 2-DG-P in the cell and the depletion in cellular ATP. In vitro, 2-Deoxyglucose has been shown to induce autophagy, increase ROS production, and activate AMPK.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

监管及禁止进口产品
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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000438958
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    0000438958
    0000438957
    0000431313

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    Craig Beall et al.
    American journal of physiology. Regulatory, integrative and comparative physiology, 302(2), R215-R223 (2011-11-11)
    Despite significant technological and pharmacological advancements, insulin replacement therapy fails to adequately replicate β-cell function, and so glucose control in type 1 diabetes mellitus (T1D) is frequently erratic, leading to periods of hypoglycemia. Moreover, the counterregulatory response (CRR) to falling
    Madhusudhanan Sukumar et al.
    The Journal of clinical investigation, 123(10), 4479-4488 (2013-10-05)
    Naive CD8+ T cells rely upon oxidation of fatty acids as a primary source of energy. After antigen encounter, T cells shift to a glycolytic metabolism to sustain effector function. It is unclear, however, whether changes in glucose metabolism ultimately
    Abdullah Farooque et al.
    Journal of cancer research and therapeutics, 5 Suppl 1, S32-S35 (2009-12-17)
    Normal tissue toxicity is one of the major limiting factors in cancer therapy. Damage to normal tissues and critical organs restricts the use of higher therapeutic doses thereby compromising the efficacy. The glucose analog 2-deoxy-D-glucose (2-DG), an inhibitor of glycolytic
    B S Dwarakanath
    Journal of cancer research and therapeutics, 5 Suppl 1, S27-S31 (2009-12-17)
    The glucose analog 2-deoxy-D-glucose (2-DG), an inhibitor of glucose transport and glycolytic ATP production, is the most widely investigated metabolic inhibitor for targeting glucose metabolism. Besides depleting energy in cells, 2-DG has also been found to alter N-linked glycosylation leading
    Alfredo J Ibáñez et al.
    Proceedings of the National Academy of Sciences of the United States of America, 110(22), 8790-8794 (2013-05-15)
    Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In this study, we demonstrate that, with the microarrays for mass spectrometry platform, we are able to observe this variability. We monitor environmentally (2-deoxy-D-glucose)
    View All Related Papers

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