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D2697

Dihydralazine sulfate

Name: Dihydralazine sulfate
Brand: SIGMA

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₂N₆O₄S

CAS Number:

7327-87-9

Molecular Weight:

288.28

EC Number:

230-808-0

UNSPSC Code:

51101500

PubChem Substance ID:

329798750

NACRES:

NA.85

form

powder

Quality Level

200

solubility

DMSO: 1 mg/mL

Mode of action

cell membrane | interferes

storage temp.

−20°C

SMILES string

OS(O)(=O)=O.NNC1=NNC(=N/N)\c2ccccc12

InChI

1S/C8H10N6.H2O4S/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7;1-5(2,3)4/h1-4H,9-10H2,(H,11,13)(H,12,14);(H2,1,2,3,4)

InChI key

BWHAMWGGORIDBK-UHFFFAOYSA-N

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Biochem/physiol Actions

Dihydralazine sulfate is a vasodilator and an antihypertensive agent. It relaxes arterial smooth muscle by inhibiting the accumulation of intracellular free calcium. By relaxing vascular smooth muscle, vasodilators act to decrease peripheral resistance.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Cerebral blood flow during dihydralazine-induced hypotension in hypertensive rats.

D I Barry et al.

Stroke, 15(1), 102-108 (1984-01-01)

The cerebrovascular effects of graded, controlled dihydralazine-induced hypotension were studied in rats with renal hypertension (RHR) and spontaneous hypertension (SHR). Repeated measurements of cerebral blood flow (CBF) were made using the intraarterial 133Xenon injection technique in anaesthetised normocapnic animals. Dihydralazine

Novel mechanism of action for hydralazine: induction of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by inhibition of prolyl hydroxylases.

Helen J Knowles et al.

Circulation research, 95(2), 162-169 (2004-06-12)

The vasodilator hydralazine, used clinically in cardiovascular therapy, relaxes arterial smooth muscle by inhibiting accumulation of intracellular free Ca2+ via an unidentified primary target. Collagen prolyl hydroxylase is a known target of hydralazine. We therefore investigated whether inhibition of other

Kinetics and Characterization of Degradation Products of Dihydralazine and Hydrochlorothiazide in Binary Mixture by HPLC-UV, LC-DAD and LC-MS Methods.

Anna Gumieniczek et al.

Chromatographia, 81(8), 1147-1162 (2018-09-18)

Dihydralazine and hydrochlorothiazide were stored at high temperature and humidity, under UV/Vis light and different pH, as individual drugs and the mixture. Then, a sensitive and selective HPLC-UV method was developed for simultaneous determination of dihydralazine and hydrochlorothiazide in presence

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