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D2625

Sigma-Aldrich

Dansyl chloride

BioReagent, suitable for amino acid labeling, powder and chunks, ≥99% (HPLC)

Synonym(s):

5-(Dimethylamino)naphthalene-1-sulfonyl chloride, DNSCl

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1 G
CN¥845.61
5 G
CN¥2,642.49
25 G
CN¥9,682.92

CN¥845.61

Available to ship onApril 27, 2025Details

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1 G
CN¥845.61
5 G
CN¥2,642.49
25 G
CN¥9,682.92

About This Item

Empirical Formula (Hill Notation):
C12H12ClNO2S
CAS Number:
605-65-2
Molecular Weight:
269.75
Beilstein:
2217205
EC Number:
210-092-6
MDL number:
MFCD00003985
UNSPSC Code:
12352101
PubChem Substance ID:
24893700
NACRES:
NA.26

CN¥845.61

Available to ship onApril 27, 2025Details

Request a Bulk Order

product line

BioReagent

Quality Level

200

Assay

≥99% (HPLC)

form

powder and chunks

color

yellow to yellow-orange

mp

72-74 °C (lit.)

solubility

acetone: 20 mg/mL

suitability

suitable for amino acid labeling

storage temp.

2-8°C

SMILES string

CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O

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This Item
39220D0125219576
Dansyl chloride BioReagent, suitable for amino acid labeling, powder and chunks, ≥99% (HPLC)

D2625

Dansyl chloride

Dansyl chloride suitable for fluorescence, BioReagent, ≥99.0% (HPLC)

39220

Dansyl chloride

Dansyl-L-alanine cyclohexylammonium salt fluorescent amino acid

D0125

Dansyl-L-alanine cyclohexylammonium salt

(1S)-(+)-10-Camphorsulfonyl chloride 97%

219576

(1S)-(+)-10-Camphorsulfonyl chloride

assay

≥99% (HPLC)

assay

≥99.0% (HPLC)

assay

≥98% (TLC)

assay

97%

product line

BioReagent

product line

BioReagent

product line

-

product line

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

form

powder and chunks

form

-

form

powder

form

solid

solubility

acetone: 20 mg/mL

solubility

acetone: 0.2 g/10 mL

solubility

-

solubility

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

Application

A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.
Dansyl chloride has been used:
  • as a fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase high performance liquid chromatography (HPLC)[1]
  • in the derivatization of plasma samples[2][3]
  • in the quantification of immobilized alkaline phosphatase[4]

Biochem/physiol Actions

Dansyl chloride is a sulfonyl chloride compound. It is used to end tag amino groups of peptides and proteins.[5] Dansyl chloride is used for derivatization of free amino acids and amines[6] in neural samples and biological fluids.[7] It is used to study fluorescent conjugates of albumin, protein conformational changes studies and active site characterization.[7]

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H290,H314

Hazard Classifications

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    BCCN1165
    BCCM9498
    BCCL1089
    BCCH0297
    BCCG9444

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    Measuring the poise of thiol/disulfide couples in vivo
    Jones DP and Liang Y
    Free radical biology & medicine, 47(10), 1329-1338 (2009)
    The use of dansyl-chloride for the detection of amino acids and serotonin in nervous tissue
    Research Methods in Neurochemistry, 443-462 (1975)
    Simultaneous separation and quantitation of amino acids and polyamines of forest tree tissues and cell cultures within a single high-performance liquid chromatography run using dansyl derivatization
    Minocha R and Long S
    Journal of Chromatography A, 1035(1), 63-73 (2004)
    The effects of different processing conditions on biogenic amine formation and some qualitative properties in pastirma
    Hazar FY, et al.
    Journal of Food Science and Technology, 54(12), 3892-3898 (2017)
    A sensitive fluorescence technique using dansyl chloride to assess hair damage
    Sandhu SS and Robbins CR
    Journal of Society of Cosmetic Chemists of Japan, 40, 287-296 (1989)
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