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D1156

Sigma-Aldrich

N,N-Dimethylglycine

≥99%, suitable for ligand binding assays

Synonym(s):

(Dimethylamino)acetic acid

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About This Item

Linear Formula:
(CH3)2NCH2COOH
CAS Number:
1118-68-9
Molecular Weight:
103.12
Beilstein:
1700261
EC Number:
214-267-8
MDL number:
MFCD00004283
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24893366
NACRES:
NA.26

product name

N,N-Dimethylglycine, ≥99%

Quality Level

200

Assay

≥99%

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

mp

178-182 °C (lit.)

application(s)

peptide synthesis

SMILES string

CN(C)CC(O)=O

InChI

1S/C4H9NO2/c1-5(2)3-4(6)7/h3H2,1-2H3,(H,6,7)

InChI key

FFDGPVCHZBVARC-UHFFFAOYSA-N

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Biochem/physiol Actions

N,N-Dimethylglycine (DMG) is a natural N-methylated glycine that is used in comparative analysis with other N-methylated glycines such as sarcosine and βine. N,N-Dimethylglycine is used in the development of glycine-based ionic liquids and emulsifiers. N,N-Dimethylglycine is potentially useful as a biomarker of protein degradation in COPD patients. DMG is used as a substrate to identify, differentiate and characterize amino acid methyltransferase(s).

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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S H Moolenaar et al.
Clinical chemistry, 45(4), 459-464 (1999-04-02)
A38-year-old man presented with a history of fish odor (since age 5) and unusual muscle fatigue with increased serum creatine kinase. Our aim was to identify the metabolic error in this new condition. We used 1H NMR spectroscopy to study
B A Binzak et al.
American journal of human genetics, 68(4), 839-847 (2001-03-07)
Dimethylglycine dehydrogenase (DMGDH) (E.C. number 1.5.99.2) is a mitochondrial matrix enzyme involved in the metabolism of choline, converting dimethylglycine to sarcosine. Sarcosine is then transformed to glycine by sarcosine dehydrogenase (E.C. number 1.5.99.1). Both enzymes use flavin adenine dinucleotide and
D Vanhauteghem et al.
Amino acids, 43(1), 245-253 (2011-09-14)
The current study first investigates the emulsifying potential of glycine and its N-methylated derivatives N-methylglycine (sarcosine), N,N-dimethylglycine (DMG) and N,N,N-trimethylglycine (betaine) under varying pH conditions. Subsequently, the effect of these test compounds on the membrane integrity of enterotoxigenic Escherichia coli
Ali A Moazzami et al.
The Journal of nutrition, 141(12), 2126-2132 (2011-10-21)
Prostate cancer (PC) is the most common cancer in the Western world and the second most important cancer causing male deaths, after lung cancer, in the United States and Britain. Lifestyle and dietary changes are recommended for men diagnosed with
Michael Lever et al.
PloS one, 7(5), e37883-e37883 (2012-06-01)
Betaine insufficiency is associated with unfavourable vascular risk profiles in metabolic syndrome patients. We investigated associations between betaine insufficiency and secondary events in acute coronary syndrome patients. Plasma (531) and urine (415) samples were collected four months after discharge following
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