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D0676

Sigma-Aldrich

Dobutamine hydrochloride

≥98%

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Synonym(s):
(±)-3,4-Dihydroxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-β-phenethylamine hydrochloride
Empirical Formula (Hill Notation):
C18H23NO3 · HCl
CAS Number:
49745-95-1
Molecular Weight:
337.84
EC Number:
256-464-1
MDL number:
MFCD00153795
UNSPSC Code:
12352116
PubChem Substance ID:
24277772
NACRES:
NA.77

Quality Level

200

Assay

≥98%

form

powder

originator

Eli Lilly

storage temp.

2-8°C

SMILES string

Cl[H].CC(CCc1ccc(O)cc1)NCCc2ccc(O)c(O)c2

InChI

1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H

InChI key

BQKADKWNRWCIJL-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153) , ADRB2(154)

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Application

Dobutamine hydrochloride has been used:
  • to treat mouse embryonic fibroblasts for cell death analysis
  • to inhibit TAZ (transcriptional coactivator with PDZ-binding motif)/YAP (Yes-associated protein) of Hippo pathway and study its effect on tumor cell proliferation
  • as β1-AR partial agonist to determine its effects on budding of endophilin-mRFP-positive structures by live-cell imaging

Biochem/physiol Actions

Dobutamine is a synthetic catecholamine that stimulate the β1 -adrenoceptor receptor. It exhibits inotropic outcome on the myocardium. Dobutamine elevates contractility and is known to be useful in the condition of low blood pressure.

Features and Benefits

This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302 + H312 + H332,H361fd

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Repr. 2

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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