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Merck
CN

D002

(±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide

solid

Synonym(s):

6,7-ADTN hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C10H13NO2 · HBr
CAS Number:
13575-86-5
Molecular Weight:
260.13
UNSPSC Code:
12352200
PubChem Substance ID:
24277893
MDL number:
MFCD00036982

Key Documents

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SMILES string

Br[H].NC1CCc2cc(O)c(O)cc2C1

form

solid

storage condition

protect from light

solubility

H2O: >10 mg/mL (Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.), aqueous base: unstable

storage temp.

2-8°C

Gene Information

human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816)

Biochem/physiol Actions

Dopamine receptor agonist.

Disclaimer

Air- and light-sensitive

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
057K4613
106K4625
081K4618

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S Patel et al.
Behavioral neuroscience, 102(4), 596-600 (1988-08-01)
The effects of administration of gamma-aminobutyric acid (GABA) compounds into the ventral pallidum and substantia innominata on the locomotor hyperactivity induced by the dopamine agonist 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene (ADTN) in the nucleus accumbens were investigated in rats. Hyperactivity induced by ADTN was
M K Boelen et al.
Brain research, 645(1-2), 240-246 (1994-05-09)
The activity of the enkephalin-immunoreactive (ENSLI) amacrine cells of the chicken retina is low in the light and high in the dark, resulting in parallel increases and decreases in the levels of the enkephalins. In vivo, the selective dopaminergic D1
A J Balmforth et al.
Journal of neurochemistry, 51(5), 1510-1515 (1988-11-01)
3,4-Dihydroxyphenylethylamine (dopamine) and beta-adrenergic receptor agonists and antagonists were assessed for their effects on cyclic AMP accumulation in human astrocytoma derived clone D384 cells. Dopamine, SKF 38393, and 2-amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene increased cyclic AMP content with Ka values of 2.0, 0.2, and
U Sreenivasan et al.
Journal of medicinal chemistry, 36(2), 256-263 (1993-01-22)
A series of analogues of the potent analogue of Pro-Leu-Gly-NH2 (PLG), 2-oxo-3(R)-[(2(S)-pyrrolidinylcarbonyl)amino]-1-pyrrolidineacet amide (2) were synthesized in which the (R)-gamma-lactam residue of 2 was replaced with a (R)-beta-lactam, (R)-aminosuccinimide, (R)-cycloseryl, (R)-delta-lactam, (R)-epsilon-lactam, or (S)-epsilon-lactam residue to give analogues 3-8, respectively.
S B Ross
Journal of neurochemistry, 56(1), 22-29 (1991-01-01)
The concentration of dopamine (DA) in the synaptic cleft in the mouse striatum in vivo was estimated from the competition between the synaptic DA and the 3H-labelled DA D2 receptor agonists N-n-propylnorapomorphine (NPA) or N,N-diethyl-N'-[(3 alpha, 4a alpha, 10 beta)-1,2,3,4,4a,5,10,10a-octahydro-
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