CNSBR009
Ampicillin sodium salt
potency: 845-988 μg per mg, powder
Synonym(s):
Blenoxane, Bleo, Blexane, D-(−)-α-Aminobenzylpenicillin sodium salt
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About This Item
Empirical Formula (Hill Notation):
C16H18N3NaO4S
CAS Number:
Molecular Weight:
371.39
UNSPSC Code:
51101500
Beilstein/REAXYS Number:
4119211
MDL number:
Form:
powder
SMILES string
[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
form
powder
potency
845-988 μg per mg
color
white to off-white
mp
215 °C (dec.) (lit.)
antibiotic activity spectrum
Gram-negative bacteria, Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
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General description
Ampicillin sodium salt is a member of the extended-spectrum β-lactam family and a semisynthetic derivative of penicillin that functions as a broad-spectrum antibiotic. It is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins (PBPs), thereby inhibiting peptidoglycan synthesis, a critical component of the bacterial cell wall. Ampicillin sodium salt is active against a wide range of Gram-positive and Gram-negative bacteria, including E.coli, β-lactam-sensitive VRE, vancomycin-resistant Enterococcus species, Staphylococcus aureus, and Streptococcus pneumoniae. It is commonly used in research laboratories to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, and the selection and maintenance of recombinant plasmids in E.coli.
Application
Ampicillin sodium salt has been used:
- to select for ampicillin resistance in mutated and transformed cells
- to select for ampicillin resistance in mutated and transformed cells
Biochem/physiol Actions
Mode of Action: This is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.
Mode of Resistance: Administration with β-lactamase cleaves the β-lactam ring of Ampicillin and inactivates it.
Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.
Mode of Resistance: Administration with β-lactamase cleaves the β-lactam ring of Ampicillin and inactivates it.
Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.
Features and Benefits
High quality antibiotic suitable for mulitple research applications.
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Danger
hcodes
Hazard Classifications
Resp. Sens. 1A - Skin Sens. 1A
Storage Class
11 - Combustible Solids
wgk
WGK 3
Regulatory Information
涉药品监管产品
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