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Merck
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CHODHFR

CHOZN® ZFN-Modified CHO Cell Line

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About This Item

NACRES:
NA.75
UNSPSC Code:
12352200
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description

CHOZN® DHFR-/- ZFN-modified CHO cell line
dihydrofolate reductase knockout cell line

shipped in

dry ice

storage temp.

−196°C

Quality Level

Biochem/physiol Actions

CHOZN cell lines are all subclones of the parental CHO-K1 cell line originated by Puck in 1957.

General description

CHOZN cell lines were created utilizing Sigma′s proprietary CompoZr Zinc Finger Nuclease (ZFN) technology to create genetic modifications in parental CHO-K1 cells. Cells are banked in chemically defined, animal component free EX-CELL CD CHO Fusion media

Legal Information

All CHOZN cell lines are sold under license from Sigma Aldrich. A copy of the research license is provided with purchase of the CHOZN cell lines.
CHOZN is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

CHOZN cell lines are provided to customers in vials containing >7.5e6 cells/mL

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

动植物来源生物产品
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Articles

A signal peptide is a 5-30 amino acid (aa) peptide present at the N-terminus of secretory proteins.

MGAT1 adds N-acetylglucosamine to the Man5GlcNAc2 (Man5) structure. Goh et al. reported increased sialylation after restoring MGAT1 function in MGAT1 deficient CHO cells.

In the present study, we have identifi ed species-specifi c housekeeping genes (HKGs) for Chinese Hamster Ovary (CHO) cells using data from microarray gene expression profiling.

Cellvento® and EX-CELL® CHO cell culture media and feeds, optimized for monoclonal antibody & recombinant protein production in fed-batch & perfusion

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Enhance mAb and recombinant protein performance, efficacy, and stability with precise glycosylation modulation using the Cellvento® ModiFeed platform.

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CHO cell genome editing

CHOZN ZFN-Modified DHFR-/- CHO Cell Line

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