C9993
Anti-CD9 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
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Synonym(s):
Anti-BA2, Anti-BTCC-1, Anti-DRAP-27, Anti-GIG2, Anti-Growth-inhibiting gene 2 protein, Anti-Leukocyte antigen MIC3, Anti-MRP-1, Anti-Motility related protein, Anti-TSPAN29, Anti-p24 antigen
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biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~25 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
immunohistochemistry: 1:100-1:250
western blot: 1:500-1:1,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CD9(928)
mouse ... Cd9(12527)
rat ... Cd9(24936)
General description
CD9 is a glioma stem cell (GSC)-enriched protein, which belongs to tetraspanin family. It is a cell motility related molecule. The gene is located on human chromosome 12p13.31. CD9 is expressed on pre-B cells, activated T cells and Schwann cells.
Immunogen
synthetic peptide corresponding to residues 36-50 of human CD9.
Application
Anti-CD9 antibody produced in rabbit has been used in
- immunostaining
- identification of hypoxia-induced mesenchymal stem cells (MSC-MVs)
Anti-CD9 antibody produced in rabbit is suitable for immunohistochemistry at a working dilution of 1:100-1:250 and western blotting at a working dilution of 1:500-1:1000. It was used as a primary antibody for the immunolocalization of adhesion protein CD9 during a study to investigate the impact of adhesion proteins on skeletal myoblast differentiation.
Biochem/physiol Actions
CD9 plays a major role in sperm-egg fusion in fertilization. It enhances cancer invasion and tumor growth in cervical cancer, gastric cancer and glioblastoma (GBM). CD9 is involved in cell invasion, apoptosis and resistance to chemotherapy.
Target description
The CD9 protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It can modulate cell adhesion and migration. It also triggers platelet activation and aggregation. In addition, the protein appears to promote muscle cell fusion and support myotube maintenance.
Physical form
solution in phosphate buffered saline, containing 0.02% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
常规特殊物品
Certificates of Analysis (COA)
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Competence of in vitro cultured mouse embryonic stem cells for myogenic differentiation and fusion with myoblasts
Archacka K, et al.
Stem Cells and Development, 23(20), 2455-2468 (2014)
Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity
Giuliano CJ, et al.
Biochimica et Biophysica Acta (BBA)-Gene Structure and Expression, 1731(1), 48-56 (2005)
Karolina Archacka et al.
Stem cells and development, 23(20), 2455-2468 (2014-06-19)
Pluripotent stem cells are a potential source of various cell types for use in regenerative medicine. Despite accumulating knowledge, there is currently no efficient and reproducible protocol that does not require genetic manipulation for generation of myogenic cells from pluripotent
CD9 suppresses human extravillous trophoblast invasion
Matsumoto H, et al.
Placenta, 47(1), 105-112 (2016)
Surface phosphatidylserine is responsible for the internalization on microvesicles derived from hypoxia-induced human bone marrow mesenchymal stem cells into human endothelial cells
Wei X, et al.
PLoS ONE, 11(1), e0147360-e0147360 (2016)
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