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C9858

Sigma-Aldrich

Creatine Kinase MM Fraction from human heart

lyophilized powder

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MDL number:
MFCD00151687
UNSPSC Code:
12352204
eCl@ss:
32160410
NACRES:
NA.54

form

lyophilized powder

Quality Level

200

specific activity

≥100 units/mg protein

UniProt accession no.

P06732

storage temp.

−20°C

Gene Information

human ... CKM(1158)

Specificity

One unit will transfer 1.0 μmole of phosphate from creatine phosphate to ADP per minute at 37 °C (measured at 340 nm as one equimolar amount of NADH produced by coupled reaction).

Application

Creatine kinase MM fraction from human heart has been used in a study to investigate the importance of intraoperative and postoperative cardiac medical therapy in emergency coronary artery bypass grafting for acute myocardial infarction. Creatine kinase MM fraction from human heart has also been used in a study to investigate the circadian dependence of infarct size and left ventricular function after ST slevation myocardial infarction.

Biochem/physiol Actions

May be used as a control or calibrator in monitoring myocardial injury.

Warning

All human source materials have tested negative for HIV1, HIV2, HCV antibodies and HbsAg. No test guarantees a product to be non-infectious. Therefore, all material derived from human fluids or tissues should be considered as potentially infectious.

Unit Definition

One unit will transfer one micromole of phosphate from creatine phosphate to ADP per minute at 37 deg C.

Physical form

Lyophilized powder containing Tris-HCl, EDTA and N-acetyl cysteine.

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品

Certificates of Analysis (COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

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    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What does the MM stand for in Product C9858, Creatine Kinase MM Fraction from human heart?

    Creatine Kinase is a dimer that exists as three isozymes: MM (muscle), MB (hybrid) and BB (brain).

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Akira Sato et al.
Journal of the American College of Cardiology, 59(8), 730-738 (2012-02-22)
This study evaluated the clinical value of myocardial contrast delayed enhancement (DE) with multidetector computed tomography (MDCT) for predicting clinical outcome after acute myocardial infarction (AMI). Although some studies have described the use of MDCT for assessment of myocardial viability
Ronald Reiter et al.
Circulation research, 110(1), 105-110 (2011-11-19)
In rodents, infarct size after ischemia/reperfusion exhibits a circadian dependence on the time of coronary occlusion. It is not known if a similar circadian dependence of infarct size occurs in humans. To determine if humans exhibit a circadian dependence of
Akira Sezai et al.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 18(4), 338-346 (2012-05-11)
The results of emergency coronary artery bypass grafting (CABG) for acute myocardial infarction (AMI) are less than satisfactory, and readmission for cardiac events is common. 105 patients underwent emergency CABG for AMI. We examined the long-term results of emergency CABG
Helen Lee et al.
The European journal of neuroscience, 31(8), 1388-1401 (2010-04-14)
Horizontal cells are lateral interneurons that participate in visual processing in the outer retina but the cellular mechanisms underlying transmitter release from these cells are not fully understood. In non-mammalian horizontal cells, GABA release has been shown to occur by

Chromatograms

application for HPLC

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