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C9755

Cytidine 5′-diphosphate sodium salt hydrate

Name: Cytidine 5&#8242;-diphosphate sodium salt hydrate
Brand: SIGMA

≥95%, from yeast, powder

Synonym(s):

CDP sodium salt hydrate

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₅N₃O₁₁P₂

Molecular Weight:

403.18

UNSPSC Code:

41106305

PubChem Substance ID:

24893191

NACRES:

NA.51

MDL number:

MFCD00069770

Assay:

≥95%

Biological source:

yeast

Form:

powder

Storage temp.:

−20°C

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Properties

Product Name

Cytidine 5′-diphosphate sodium salt hydrate, from yeast, ≥95%

biological source

yeast

Quality Level

200

assay

≥95%

form

powder

storage temp.

−20°C

SMILES string

[Na].NC1=NC(=O)N(C=C1)C2OC(COP(O)(=O)OP(O)(O)=O)C(O)C2O

InChI

1S/C9H15N3O11P2.Na.H/c10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H2,10,11,15)(H2,16,17,18);;

InChI key

MAGSIBHRUIBONY-UHFFFAOYSA-N

Description

General description

Cytidine 5′-diphosphate (CDP) is synthesized from cytidine monophosphate (CMP) or uridine monophosphate (UMP) by the transfer of phosphoryl group, catalyzed by the enzyme uridylate kinase (UMPK). CTP synthetase catalyzes the conversion of CTP to CDP intermediates like CDP-diacylglycerol, CDP-choline and CDP-ethanolamine for phospholipid biosynthesis.

Application

Cytidine 5′-diphosphate sodium salt hydrate has been used:

as a substrate in nucleoside diphosphatase (NDPase) enzyme histochemistry assay of gold fish eye sections
in ribonucleotide reductase assay
dCDP formation assay.

Biochem/physiol Actions

Cytidine 5′-diphosphate (CDP) is used as a substrate of nucleoside diphosphatase kinase to produce CTP for supporting DNA and RNA biosynthesis and of ribonucleotide reductase to product dCMP.

Storage Class

11 - Combustible Solids

ppe

Eyeshields, Gloves, type N95 (US)

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Protocols

LC/MS Analysis of Nucleotides on SeQuant ZIC-cHILIC

HILIC separation is an alternative that permits sensitive MS detection and without the use of ion-pair reagents.

LC/MS Analysis of Nucleotides SeQuant^® ZIC^®-cHILIC – Effect of pH

ZIC^®-cHILIC is a densely bonded zwitterionic stationary phase with phosphorylcholine functional groups covalently attached to silica.

Microglial cells in the retina of Carassius auratus: effects of optic nerve crush

Salvador-Silva M, et al.

The Journal of Comparative Neurology, 417(4), 431-447 (2000)

Bacillus subtilis class Ib ribonucleotide reductase is a dimanganese(III)-tyrosyl radical enzyme.

Yan Zhang et al.

Biochemistry, 50(25), 5615-5623 (2011-05-13)

Bacillus subtilis class Ib ribonucleotide reductase (RNR) catalyzes the conversion of nucleotides to deoxynucleotides, providing the building blocks for DNA replication and repair. It is composed of two proteins: α (NrdE) and β (NrdF). β contains the metallo-cofactor, essential for

Ribonucleotide reductase requires subunit switching in hypoxia to maintain DNA replication

Foskolou IP, et al.

Molecular Cell, 66(2), 206-220 (2017)

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Global Trade Item Number

SKU	GTIN
C9755-25MG	04061833261262
C9755-100MG	04061833261255