C9477
Anti-Chloride Channel-2 (CLC-2, Clcn2) antibody produced in rabbit
affinity isolated antibody, lyophilized powder
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About This Item
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biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
western blot (chemiluminescent): 1:200-1:400 using rat membranes and ECL
UniProt accession no.
storage temp.
−20°C
Gene Information
rat ... Clcn2(29232)
Immunogen
synthetic peptide corresponding to amino acids 888-906 of the rat chloride channel-2 (CLC-2).
Application
Anti-Chloride Channel-2 antibody produced in rabbit is suitable for western blot (chemiluminescent) at a working dilution of 1:200-1:400 using rat membranes and ECL.
Biochem/physiol Actions
The encoded protein, voltage-gated chloride channel, is a transmembrane protein that maintains chloride ion homeostasis in various cells. Defects in this gene may be a cause of certain epilepsies. Autosomal-recessive mutations ion this gene cause a leukoencephalopathy that affects brain ion and water homoeostasis. It is characterized by intramyelinic oedema. It is involved in maintaining the volume of trabecular meshwork cells by adjusting the outflow of aqueous solutions and for maintaining the fluid balance. It may be a potential target for the treatment of primary open angle glaucoma.
Physical form
Lyophilized at ~0.6 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Regulatory Information
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Hong Wei Wang et al.
Molecular medicine reports, 8(4), 1099-1105 (2013-08-13)
The chloride channel protein 2 (CLC‑2) is important in maintaining the volume of trabecular meshwork cells by adjusting the outflow of aqueous solutions and maintaining the fluid balance. However, little is known concerning the functions of CLC‑2 in the cytoskeleton
Cécile Saint-Martin et al.
Human mutation, 30(3), 397-405 (2009-02-05)
Heterozygous mutations in the CLCN2 gene encoding the voltage-gated chloride channel CLC2 have been identified in patients with idiopathic generalized epilepsy (IGE). Yet the involvement of CLCN2 in epilepsy remains controversial. To investigate the involvement of CLCN2 in another independent
Christel Depienne et al.
The Lancet. Neurology, 12(7), 659-668 (2013-05-28)
Mutant mouse models suggest that the chloride channel ClC-2 has functions in ion and water homoeostasis, but this has not been confirmed in human beings. We aimed to define novel disorders characterised by distinct patterns of MRI abnormalities in patients
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