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C9377

Sigma-Aldrich

Chenodeoxycholic acid

Synonym(s):

3α,7α-Dihydroxy-5β-cholanic acid, 5β-Cholanic acid-3α,7α-diol, Chenodiol

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1 MG
CN¥669.75
5 MG
CN¥2,560.22
10 MG
CN¥4,050.78

CN¥669.75

Estimated to ship onJuly 02, 2025Details

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1 MG
CN¥669.75
5 MG
CN¥2,560.22
10 MG
CN¥4,050.78

About This Item

Empirical Formula (Hill Notation):
C24H40O4
CAS Number:
474-25-9
Molecular Weight:
392.57
Beilstein:
3219887
EC Number:
207-481-8
MDL number:
MFCD00064142
UNSPSC Code:
12352106
PubChem Substance ID:
24893153
NACRES:
NA.25

CN¥669.75

Estimated to ship onJuly 02, 2025Details

New, lower price on this item!
Request a Bulk Order

description

anionic

form

powder

mol wt

392.57 g/mol

technique(s)

protein quantification: suitable

CMC

(3)
3

mp

165-167 °C (lit.)

functional group

carboxylic acid

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@H](CCC(O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

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species reactivity

human, mouse

species reactivity

human, Xenopus

species reactivity

human, zebrafish, mouse, Xenopus, chicken, fish

species reactivity

human

clone

monoclonal

clone

monoclonal

clone

monoclonal

clone

1.2.1.5.4, monoclonal

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

technique(s)

ChIP: suitable, immunoprecipitation (IP): suitable, dot blot: suitable, western blot: suitable

technique(s)

ChIP: suitable (ChIP-seq), immunoprecipitation (IP): suitable

technique(s)

ChIP: suitable, immunoprecipitation (IP): suitable, western blot: suitable

technique(s)

ChIP: suitable, ELISA: suitable, dot blot: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, multiplexing: suitable, western blot: suitable

Gene Information

human ... TCF7L2(6934)

Gene Information

-

Gene Information

human ... TBP(6908)

Gene Information

human ... CTCF(10664)

General description

Chenodeoxycholic acid is a bile acid synthesized in the liver from cholesterol. [1]

Application

Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX). [2] It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies. [3]

Biochem/physiol Actions

Bile Acid

related product

Product No.
Description
Pricing

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves
  • Specification Sheet

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000376657
    0000376670
    0000350734
    0000337366
    0000337680

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    M O Osman et al.
    Gut, 43(2), 232-239 (1999-04-06)
    Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. To define the role of IL-8 in acute pancreatitis by neutralising its effects with a
    Gallstone dissolution in man using chenodeoxycholic acid
    Bell, G., et al.
    Lancet, 300, 1213-1213 null
    A Stiehl et al.
    Gastroenterology, 98(2), 424-428 (1990-02-01)
    The effects of ursodeoxycholic acid and chenodeoxycholic acid on the small-intestinal absorption of endogenous bile acids were studied in patients with ileostomies who served as a model to investigate small-intestinal absorption in humans. In the control period, the eight patients
    Wei Zhou et al.
    Journal of biomolecular screening, 15(5), 488-497 (2010-05-08)
    Dietary long-chain fatty acid (LCFA) uptake across cell membranes is mediated principally by fatty acid transport proteins (FATPs). Six subtypes of this transporter are differentially expressed throughout the human and rodent body. To facilitate drugs discovery against FATP subtypes, the
    Roberto Pellicciari et al.
    Journal of medicinal chemistry, 52(24), 7958-7961 (2009-12-18)
    In the framework of the design and development of TGR5 agonists, we reported that the introduction of a C(23)(S)-methyl group in the side chain of bile acids such as chenodeoxycholic acid (CDCA) and 6-ethylchenodeoxycholic acid (6-ECDCA, INT-747) affords selectivity for
    View All Related Papers

    Protocols

    HPLC Separation of Bile Acids with Ascentis Express C18

    Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

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    Bile Acids Kit for LC-MS

    Bile Acids (BA) are synthesized in the liver and play important roles in cholesterol homeostasis, absorption of vitamins and lipids, and various key metabolic processes.

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