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Safety Information

C9369

Sigma-Aldrich

CCT007093

≥98% (HPLC), powder, yellow

Synonym(s):

(2E,5E)-2,5-Bis(2-thienylmethylene)-cyclopentanone

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About This Item

Empirical Formula (Hill Notation):
C15H12OS2
CAS Number:
176957-55-4
Molecular Weight:
272.39
MDL number:
MFCD00121546
UNSPSC Code:
12352200
PubChem Substance ID:
329775204
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

powder, yellow

solubility

DMSO: >3 mg/mL

storage temp.

2-8°C

SMILES string

O=C1\C(CC\C1=C/c2cccs2)=C\c3cccs3

InChI

1S/C15H12OS2/c16-15-11(9-13-3-1-7-17-13)5-6-12(15)10-14-4-2-8-18-14/h1-4,7-10H,5-6H2/b11-9+,12-10+

InChI key

KPFZCKDPBMGECB-WGDLNXRISA-N

Application

CCT007093 has been used as a wild-type p53-induced phosphatase (Wip1) inhibitor to study its effect on skin keratinocytes, under ultra-violet (UV) stress conditions. It has also been used as a Wip1 inhibitor in time course inhibition assay to evaluate the effect of Wip1 inhibition on expression of AKT serine/threonine kinase 1(Akt1) and glycogen synthase kinase-3β (GSK-3β)and the phosphorylation of GSK-3β at serine 9 (Ser9) and Akt at Ser473.

Biochem/physiol Actions

CCT007093 inhibits the growth of cancer cell lines (MCF-7, KPL-1, and MCF-3B) that overexpress protein phosphatase, Mg2+/Mn2+ dependent 1D (PPM1D). It induces cancer cell death via the activation of p38 kinase activity.
CCT007093 is an effective PPM1D inhibitor that selectively reduces viability of human tumour cell lines.
CCT007093 is an effective protein phosphatase, Mg2+/Mn2+ dependent, 1D (PPM1D) inhibitor that selectively reduces viability of human tumour cell lines.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Serine/Threonine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000134623
0000054132
013M4611V
088K46132
088K46131

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S Rayter et al.
Oncogene, 27(8), 1036-1044 (2007-08-19)
The PPM1D gene is aberrantly amplified in a range of common cancers and encodes a protein phosphatase that is a potential therapeutic target. However, the issue of whether inhibition of PPM1D in human tumour cells that overexpress this protein compromises
Ji-Seon Lee et al.
Journal of dermatological science, 73(2), 125-134 (2013-10-16)
The wild type p53 inducible phosphatase (Wip1) plays an important role in modulating not only stress responses by various environmental stresses, but when overexpressed it also impairs the intrinsic tumor surveillance networks that are frequently found in a number of
Joshua A Bauer et al.
Breast cancer research : BCR, 12(3), R41-R41 (2010-06-26)
Paclitaxel is a widely used drug in the treatment of patients with locally advanced and metastatic breast cancer. However, only a small portion of patients have a complete response to paclitaxel-based chemotherapy, and many patients are resistant. Strategies that increase
Sheng Yin et al.
Oncotarget, 7(20), 29359-29370 (2016-04-29)
Inactivation of p53 greatly contributes to serous ovarian cancer, while the role of the wild-type p53 induced phosphatase 1 (Wip1) is quite unclear. In this study, by silencing or overexpression of Wip1, we found that Wip1 suppressed ovarian cancer cell
ET-69SPECIFIC Wip1 INHIBITOR, CCT007093 ABROGATE CELL PROLIFERATION, MIGRATION AND INVASION INDUCED BY THE UVC RADIATION IN HUMAN GLIOBLASTOMA CELLS
Yang L, et al.
Neuro-Oncology, 16, v94-v94 (2014)
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