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Merck
CN

C9275

Calcium Ionophore A23187 hemicalcium salt

powder

Synonym(s):

A23187 hemicalcium salt, Antibiotic A 23187 hemicalcium salt, Calcimycin hemicalcium salt, Calimycin hemicalcium salt

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About This Item

Empirical Formula (Hill Notation):
C29H36Ca0.5N3O6
CAS Number:
59450-89-4
Molecular Weight:
542.65
UNSPSC Code:
12352200
NACRES:
NA.32
PubChem Substance ID:
24893145
MDL number:
MFCD00077678
Beilstein/REAXYS Number:
6765084

Key Documents

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Product Name

Calcium Ionophore A23187 hemicalcium salt, powder

InChI

1S/2C29H37N3O6.Ca/c2*1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;/h2*6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);/q;;+2/p-2/t15-,16-,17-,18-,22-,27+,29?;15-,16-,17-,18-,22-,27+,29+;/m11./s1

SMILES string

CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(=O)O[Ca]OC(=O)c6c(NC)ccc7oc(C[C@H]8O[C@@]9(CC[C@H]8C)O[C@@H]([C@H](C)C[C@H]9C)[C@H](C)C(=O)c%10ccc[nH]%10)nc67

InChI key

LAQWEYASNNRUGY-PLYBNSMSSA-L

sterility

non-sterile

form

powder

color

yellow

solubility

DMSO: soluble
ethanol: soluble

antibiotic activity spectrum

Gram-positive bacteria
fungi

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

200

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Application

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.
Ionophore highly selective for Ca2+. Stimulates nitric oxide production in cells by calmodulin-dependent constitutive nitric oxide synthase.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000319842
0000297984
0000319842
0000297984
0000148981

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Lin Cai et al.
International journal of clinical oncology, 25(6), 1055-1066 (2020-02-28)
Filamin A is the most widely expressed isoform of filamin in mammalian tissues. It can be hydrolyzed by Calpain, producing a 90-kDa carboxyl-terminal fragment (ABP90). Calpeptin is a chemical inhibitor of Calpain, which can inhibit this effect. It has been
Jing Dai et al.
American journal of human genetics, 108(3), 469-481 (2021-02-25)
Total fertilization failure (TFF) can occur during in vitro fertilization (IVF) treatments, even following intracytoplasmic sperm injection (ICSI). Various male or female factors could contribute to TFF. Increasing evidence suggested that genetic variations in PLCZ1, which encodes 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
Hong Liu et al.
American journal of physiology. Heart and circulatory physiology, 319(6), H1482-H1495 (2020-10-17)
Multiple organ perfusion is impaired in sepsis. Clinical studies suggest that persistent perfusion disturbances are prognostic of fatal outcome in sepsis. Pyroptosis occurs upon activation of caspases and their subsequent cleavage of gasdermin D (Gsdmd), resulting in Gsdmd-N (activated NH2-terminal
Quan-Fang Zhang et al.
Frontiers in plant science, 11, 145-145 (2020-03-13)
Ceramide sphingolipids are major components of membranes. C2 and C6 ceramides induce programmed cell death (PCD) in animals and plants, and we previously showed that C2 and C6 ceramides induce PCD in rice (Oryza sativa) protoplasts. However, the mechanistic link

Related Content

Data Sheet - C9275

Instructions

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