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C8742

Sigma-Aldrich

CHIC-35

≥97% (chiral, HPLC)

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Synonym(s):
(6S)-2-Chloro-5,6,7,8,9,10-hexahydro-cyclohept[b]indole-6-carboxamide, Compound (S)-35
Empirical Formula (Hill Notation):
C14H15ClN2O
CAS Number:
848193-72-6
Molecular Weight:
262.73
MDL number:
MFCD11045286
UNSPSC Code:
12352200
PubChem Substance ID:
329775186
NACRES:
NA.77

Quality Level

100

Assay

≥97% (chiral, HPLC)

form

solid

solubility

DMSO: >10 mg/mL
H2O: <2 mg/mL

storage temp.

2-8°C

SMILES string

ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1

InChI

1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1

InChI key

ABIVOOWWGYJNLV-JTQLQIEISA-N

Biochem/physiol Actions

CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.

Features and Benefits

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WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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