C8180
Cholera Toxin A Subunit from Vibrio cholerae
lyophilized powder
form
lyophilized powder
composition
Protein, ~5% Lowry
availability
not available in Japan
impurities
≤0.5% Cholera toxin B subunit (SDS-PAGE)
storage temp.
2-8°C
Quality Level
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General description
Cholera Toxin (CT) is secreted by Vibrio cholerae. CT upregulates cell surface molecules, such as co-stimulatory molecules and chemokine receptors in antigen presenting cells(APCs), murine and human dendritic cells (DCs). It enhances the secretion of interleukin 1 (IL-1) from macrophages and stimulates their APC function. CT also functions as an immunomodulator.
Application
Cholera Toxin A Subunit from Vibrio cholerae has been used as a specific probe for trimeric G proteins in membrane motility assays.
Biochem/physiol Actions
Catalyzes ADP-ribosylation of the α-subunit of G proteins, reducing GTPase activity and activating the α-subunit; also catalyzes ADP-ribosylation of cell membrane adenylyl cyclase
Physical form
Lyophilized powder containing Tris buffer salts, sodium chloride, sodium azide and sodium EDTA
Preparation Note
When reconstituted with 1 mL of water, the solution will contain 0.05 M Tris buffer salts, pH 7.5, 0.2 M NaCl, 0.003 M NaN3, and 0.001 M sodium EDTA. Store reconstituted solutions in the refrigerator.
flash_point_f
Not applicable
flash_point_c
Not applicable
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Acute Tox. 4 Inhalation - Aquatic Chronic 3
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Regulatory Information
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In Vitro Reconstitution of Microtubule Plus End-directed, GTPgammaS-sensitive Motility of Golgi Membranes
Fullerton AT, et al.
Molecular Biology of the Cell, 9(10), 2699-2714 (1998)
Actions of cholera toxin and the prevention and treatment of cholera
Holmgren J.
Nature, 292(5822), 413-413 (1981)
Cholera toxin: a paradigm of a multifunctional protein
Bharati K and Ganguly NK
The Indian Journal of Medical Research, 133(2), 179-179 (2011)
Irina N Marinova et al.
STAR protocols, 2(3), 100668-100668 (2021-09-07)
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