Skip to Content
Merck
CN

C7897

Clonidine hydrochloride

α2-adrenoceptor agonist, solid

Synonym(s):

2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride

Sign In to View Organizational & Contract Pricing.

Select a Size

About This Item

Empirical Formula (Hill Notation):
C9H9Cl2N3 · HCl
CAS Number:
4205-91-8
Molecular Weight:
266.55
NACRES:
NA.77
PubChem Substance ID:
24277750
UNSPSC Code:
12352200
EC Number:
224-121-5
MDL number:
MFCD00036705
Beilstein/REAXYS Number:
4163525

Key Documents

View All Documentation
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

Clonidine hydrochloride, solid

InChI key

ZNIFSRGNXRYGHF-UHFFFAOYSA-N

InChI

1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H

SMILES string

Cl[H].Clc1cccc(Cl)c1NC2=NCCN2

form

solid

color

white

solubility

H2O: soluble
methanol: soluble

originator

Boehringer Ingelheim

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Looking for similar products? Visit Product Comparison Guide

Related Categories

Application

Clonidine hydrochloride has been used as an adrenergic receptor (ADRA2A) agonist:
  • in ex vivo leptin release assay
  • to study its effects on pain hypersensitivity in 6-OHDA lesioned rats
  • to study its influence on the sleep of larval zebrafish
  • to manipulate noradrenaline and examine its influence on behavioral flexibility and motivation

Clonidine hydrochloride has been used:
  • to reduce central noradrenaline levels
  • to inhibit allyl isothiocyanate (AITC) sensitized thermal aversion
  • to attenuate thermal and mechanical pain hypersensitivity in rats
  • as a positive control for pertussis toxin (PTX)

Biochem/physiol Actions

α2-adrenoceptor agonist; I1 imidazoline binding site ligand.
Clonidine hydrochloride is used for management of hypertension in pregnant women. In addition, it also acts as a therapeutic for neonatal abstinence syndrome. Clonidine hydrochloride binds to central α-adrenergic receptors and reduces the efferent sympathetic neuronal vasoconstrictor tone to the heart, kidneys and peripheral vasculature leading to vasodilatation and reduction in the blood pressure.

Features and Benefits

This compound is featured on the Imidazoline Binding Sites page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

General description

Clonidine hydrochloride has antihypertensive analgesic and antidiarrheal properties. It lowers short-circuit current, blocks anion secretion, improves mucosal absorption of fluids and electrolytes in vitro. Clonidine is used to treat attention deficit and hyperactivity disorders (ADHD), menopausal flushing, drug withdrawal and Tourette′s syndrome.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCV4522
MKCT7664
MKCQ6586
MKCS3498
MKCN7082

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Evaluation of clonidine hydrochloride (Catapres): a new antihypertensive agent
Kosman ME
JAMA : The Journal of the American Medical Association, 233(2), 174-176 (1975)
Chemerin-induced arterial contraction is Gi-and calcium-dependent
Ferland DJ, et al.
Vascular Pharmacology, 88, 30-41 (2017)
Restoring spinal noradrenergic inhibitory tone attenuates pain hypersensitivity in a rat model of Parkinson?s disease
Ca Lei-Fang, et al.
Neural Plast., 2016(5), e33710-e33710 (2016)
Intra-articular morphine and clonidine produce comparable analgesia but the combination is not more effective
Gentili M, et al.
British journal of anaesthesia, 79(5), 660-661 (1997)
Z P Khan et al.
Anaesthesia, 54(2), 146-165 (1999-04-24)
Clonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well as in chronic pain therapy because it has both anaesthetic and analgesic-sparing activity. The more selective alpha-2 adrenoceptor agonists, dexmedetomidine and mivazerol, may also have
View All Related Papers

Related Content

Product Information Sheet - C7897

Product Information Sheet

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service